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Review Paper

Effect of plant polyphenols on seizures – animal studies

Introduction. Flavonoids are a large group of natural compounds that have been considered to be beneficial in ameliorating some age-dependent disorders. However, a potential use of these compounds in epilepsy treatment has not been systematically reviewed. Aim. This review describes the pharmacological activity of some polyphenols (flavonoids) in different animal models of seizures e.g. pentylenetetrazole-induced seizures, kainate-induced seizures and pentylenetetrazole kindling in rats. Method

Władysław Lasoń, Monika Leśkiewicz

Journal of Epileptology, Volume 21 , ISSUE 2, 79–87


Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol-kindled rats

-Herrera et al., 2004, 2010; Besio et al., 2013; Gersner et al., 2016). These data point to the potential for the development of new and better therapies for drug-resistant seizures (Asgari et al., 2014, 2016). This study presents the first analysis of BDZ-GABAA-dependent mechanisms of seizure inhibition in response to paleocerebellar ES. To test this, we used the PTZ-induced kindling rat model since PTZ is a selective antagonist of the GABAA receptor-chloride ionophore complex (Erkec and Arihan, 2015

Leonid S. Godlevsky, Oleksii O. Shandra, Mykhailo P. Pervak, Alexey A. Shandra

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 322–330


Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats

action (Toprani and Durand, 2013) or depotentiation (Rogawski, 2002). NMDA receptors (NMDAR), GABA receptors (GABAR) and calcineurin may be involved in these types of synaptic plasticity. Many patients with TLE suffer from memory impairments (Giovagnoli and Avanzini, 1999) that are commonly attributed to neural hyperexcitability in the hippocampus following seizure activity (Mazarati, 2008). Many studies have shown that kindling leads to time-dependent memory deficits (Leung and Shen, 1991; Leung et

Mona Faraz, Nastaran Kosarmadar, Mahmoud Rezaei, Meysam Zare, Mohammad Javan, Victoria Barkley, Amir Shojaei, Javad Mirnajafi-Zadeh

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 43–57

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