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  • Acta Neurobiologiae Experimentalis

 

research-article | 15-October-2020

Subchronic effects of ligands of cannabinoid receptors on learning and memory processes of olfactory bulbectomized rats

INTRODUCTION Endocannabinoid system (ECS) plays role in many physiological processes, including mood, learning and memory. It is also involved in the pathogenesis of anxiety and mood disorders, as well as neurodegenerative disorders (Hill and Gorzalka, 2009; Ranieri et al., 2016). ECS consists of the endogenous cannabinoids (endocannabinoids), cannabinoid receptors and the enzymes that synthesize and degrade endocannabinoids. The cannabinoid receptors (CB1 and CB2) belong to the class of G

Margarita Velikova, Dobrinka Doncheva, Roman Tashev

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 286–296

research-article | 07-July-2020

Effects of sex steroid hormones on memory

, gonadal hormones are also assumed to have an influence on many cerebral function. Finally, even though much of the evidence on gonadal-induced neuroplasticity, related to learning and memory processes, centers on the effect of estrogens, data related to neurotrophic actions of androgens also exist (Colciago et al., 2015). Role of estrogens in memory processes Many studies have suggested that estrogens have a role on many cognitive functions, including learning and memory (Gasbarri et al., 2008a

Assunta Pompili, Carla Iorio, Antonella Gasbarri

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 117–128

research-article | 30-November-2020

Regular aerobic exercise increased VEGF levels in both soleus and gastrocnemius muscles correlated with hippocampal learning and VEGF levels

INTRODUCTION Many aspects of the health benefits of exercise are known, such as those in endocrine and cardiovascular systems, as well as metabolic and developmental functions (Hughes et al., 1993; Ostergard et al., 2006; Labonte-Lemoyne et al., 2017; Lin and Lee, 2018). In recent years, scientific research has focused on the effects of exercise on the neurocognitive process. Exercise has been shown to improve learning and memory function by increasing neurogenesis and angiogenesis in the

Asli Karakilic, Oguz Yuksel, Servet Kizildag, Ferda Hosgorler, Birsu Topcugil, Rabia Ilgin, Hikmet Gumus, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates, Nazan Uysal

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 1–9

research-article | 30-November-2020

Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats

al., 1994; Gilbert et al., 2000). Learning and memory are highly complex processes. Each is accompanied by changes in brain activity, including synaptic plasticity in the form of long-term potentiation (LTP) and LTD (Kemp and Manahan-Vaughan, 2007). Previous studies showed that NMDARs play an important role in synaptic plasticity (Hunt and Castillo, 2012), learning and memory (Li and Tsien, 2009), and epileptogenesis (Frasca et al., 2011). Changes in the NR2A to NR2B subunits ratio affect the

Mona Faraz, Nastaran Kosarmadar, Mahmoud Rezaei, Meysam Zare, Mohammad Javan, Victoria Barkley, Amir Shojaei, Javad Mirnajafi-Zadeh

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 43–57

Research paper | 18-May-2018

Possible role of hippocampal GPR55 in spatial learning and memory in rats

Endocannabinoids (eCBs) are involved in the hippocampal mechanisms of spatial learning and memory in rats. Although eCBs exert many of their actions on spatial learning and memory via CB1 receptors, the putative cannabinoid receptor GPR55 (expressed in the hippocampus, cortex, forebrain, cerebellum and striatum) seems to be also involved. To investigate the potential role of GPR55 in spatial learning and memory, Wistar rats received bilateral infusions of lysophosphatidylinositol (LPI, GPR55

Bruno A. Marichal-Cancino, Alfonso Fajardo-Valdez, Alejandra E. Ruiz-Contreras, Mónica Méndez-Díaz, Oscar Prospéro-García

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 1, 41–50

Review | 15-January-2019

c-Fos and neuronal plasticity: the aftermath of Kaczmarek’s theory

The development of molecular biology methods in the early 1980s led to a better understanding of the role of transcription factors in mammalian cells. The discovery that some transcription factors are critically important for cells to switch between different functional states was fundamental for modern molecular neurobiology. In the 1980s Leszek Kaczmarek proposed that, analogically to the cell cycle or to cell differentiation, long-term synaptic plasticity, learning, and memory should also

Jacek Jaworski, Katarzyna Kalita, Ewelina Knapska

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 287–296

research-paper | 30-November-2020

Role of NR2B/ERK signaling in the neuroprotective effect of dexmedetomidine against sevoflurane induced neurological dysfunction in the developing rat brain

various brain injuries, it is still unknown whether DEX can directly protect against cognitive dysfunction induced by sevoflurane exposure, especially in developing brain. Notably, in the depression model of rats treated by chronic unpredictable mild stress, DEX is suggested to protect against learning and memory impairment caused by electroconvulsive shock in depressed rats, with the involvement of the NMDA receptor subunit 2B (NR2B)-ERK signaling pathway (Gao et al., 2016). In light of the above

Guohua Li, Fang Cao, Yanwu Jin, Yu Wang, Dawei Wang, Limin Zhou

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 271–278

research-paper | 30-November-2020

Brain-derived neurotrophic factor and nitric oxide contribute to protective effects of rosiglitazone on learning and memory in hypothyroid rats

alterations, which lead to behavioral abnormalities, including learning and memory impairment (Ahmed et al., 2008; Ritchie and Yeap, 2015). These hormones regulate the growth factor expression and synaptogenesis in learning and memory-related brain areas, including the hippocampus and cortex (Forrest and Vennström, 2000; Parent et al., 2011). The hippocampus appears to be more sensitive than the cortex to thyroid hormone depletion (Zhang et al., 2009; Parent et al., 2011). The exact mechanism of cognitive

Yousef Baghcheghi, Farimah Beheshti, Hossein Salmani, Mahmoud Hosseini

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 218–232

Research paper | 15-January-2019

Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer’s disease

established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt’s forced swim, and Morris’ water maze, to evaluate anxietyand depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer’s-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment

Yasemin Bilgic, Enver Ahmet Demir, Nilufer Bilgic, Hatice Dogan, Okan Tutuk, Cemil Tumer

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 322–331

research-article | 30-November-2019

Serotonin and noradrenaline content and release in the dorsal hippocampus during learning and spatial memory in prenatally stressed rats

INTRODUCTION In rodents, maternal stress during pregnancy can cause psychopathologies in the offspring, such as anxiety and depressive-like behaviors, as well as cognitive deficits (Weinstock, 2017). Also, alterations in development and maturation of brain structures, such as the hippocampus, have been reported (Fujioka et al., 2006). The dorsal hippocampus is involved in spatial learning and memory processes in rats and primates (Bannerman et al., 2004; Tanti and Belzung, 2013; Grigoryan and

Diana Méndez Guerrero, Felipe de Jesús Jiménez Vásquez, Moisés Rubio Osornio, María del Carmen Rubio Osornio, Sandra Orozco Suárez, Socorro Retana-Márquez

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 400–410

research-article | 26-March-2021

Aminoguanidine ameliorates ovariectomy-induced neuronal deficits in rats by inhibiting AGE-mediated Aβ production

interactions (Yun et al., 2018). Sarkar et al. (2015) discovered that the oestrogen-induced amelioration of Aβ-induced damage in mitochondria is regulated by mitochondrial signalling pathways and oxidative phosphorylation involving estrogen receptor (ER) β and A kinase anchoring protein (AKAP). Further research suggested that oestrogen may protect against learning and memory impairment through the regulation of Aβ deposition and neuroinflammation by inhibiting nuclear factor kappa B (NF-κB) activity in

Dan Di Zhang, Yan Gang Wang, Chun Yan Liu, Ze Hou Wang, Yue Fen Wang

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 10–20

Research paper | 25-July-2017

Pharmacokinetics and pharmacodynamics of a novel Acetylcholinesterase Inhibitor, DMNG-3

DMNG-3 (3β-Methyl-[2-(4-nitrophenoxy)ethyl]-amino]con-5-enine), is a new and the potentially most potent acetylcholinesterase inhibitor recently obtained from conessine by N-demethylation and nucleophilic substitution reaction. In the present study, a step‑down passive avoidance test was used to investigate whether DMNG-3 could modulate impairment of learning and memory induced by scopolamine, and a high performance liquid chromatography (HPLC) method for the determination of DMNG-3 in

Xin-Guo Zhang, Fei Kou, Guo-Di MA, Peng Tang, Zhong-Duo Yang

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 2, 117–124

research-article | 24-June-2021

Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels

acetylcholine and glutamate release and induce long-term potentiation (LTP) (Jackson et al., 2018). In addition, inadequate AT4R signaling may lead to impaired neurotransmitter release and synaptic dysfunction, which may lead to impaired cognitive function. Previous studies on the positive effects of Ang IV on learning and memory have led to the question of whether it might play a curative role in cognitive disorders that develop in DM. Therefore, in this study, we aimed to investigate the effect of Ang IV

Aysu Kilic, Savas Ustunova, Birsen Elibol, Huri Bulut, Ismail Meral, Gulderen Sahin

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 2, 1–11

Research paper | 22-August-2018

Administration of muscarinic antagonists induce changes in passive avoidance learning and in synaptic transmission in the CA1 area of the hippocampus

Muscarinic acetylcholine receptors (mAChR) are known to be related to learning and memory processes. Inactivation of mAChR by cholinergic antagonists have been shown to produce amnesia in a variety of behavioral tasks. In this study, we investigated the role of M1 and M2 AChR on passive avoidance learning and plasticity of synapses formed by Schaffer collaterals in freely moving rats. Experiments were performed using Wistar male rats. Seven days before testing, a recording electrode was lowered

Yulia V. Dobryakova, Olga Y. Ivanova, Vladimir A. Markevich

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 2, 132–139

Research paper | 04-May-2018

Antimuscarinic-induced convulsions in fasted mice after food intake: no evidence of spontaneous seizures, behavioral changes or neuronal damage

Prolonged or repeated seizures have been shown to cause spontaneous recurrent seizures, increased anxiety-related behavior, locomotor hyperactivity, impaired functions of learning and memory, and neuronal damage in the hippocampus and other brain regions in animals. Mice and rats treated with antimuscarinic drugs after fasting for two days or less develop convulsions after being allowed to eat ad libitum. To address whether such behavioral and neuroanatomic changes occur following these

Nurhan Enginar, Asiye Nurten, Aslı Zengin Türkmen, Gül İpek Gündoğan, Zeynep Güneş Özünal

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 373–381

research-paper | 30-November-2020

An Aβ3-10-KLH vaccine decreases Aβ plaques and astrocytes and microglia activation in the brain of APP/PS1 transgenic mice

of China Medical University until they were 10 months old. The animal experiments were approved by the Animal Ethics Committee of China Medical University and performed according to the guidelines of the Animal Care and Use Committee of China Medical University. Morris water maze test The spatial learning and memory abilities of the APP/PS1 transgenic mice and WT mice were detected by the Morris water maze test at the age of 10 months. In this experiment, the Morris water maze test system

Yang Wang, Bing Xu, Jin Zhou, Jinchun Wang, Guoqing Wang, Yunpeng Cao

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 207–217

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