Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone. Antinociceptive activity was assessed by the formalin test in male Wistar rats (200–250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related
Katarina Savić Vujović,
Acta Neurobiologiae Experimentalis , ISSUE 2, 137–146
Previously we described the antinociceptive effect of magnesium sulfate and dizocilpine (MK-801) in the visceral and somatic rat models of pain. In the somatic model of pain, we established the influence of selective inhibitors of neuronal and inducible nitric oxide synthase on the antihyperalgesic effects of magnesium sulfate and dizocilpine. Therefore, the objective of the present study was to determine in the rat model of visceral pain whether same mechanisms are involved in the
Acta Neurobiologiae Experimentalis , ISSUE 2, 110–116
given together with data indicating the similarity between lithium and magnesium cations. In this context, similarities and dissimilarities between the useful “poison” with narrow therapeutic window (Li+) and the bivalent cation acting like cofactor of more than 300 enzymatic reactions (Mg2+) are pointed out together with results indicating enhanced activity of trimeric G proteins in bipolar disorder.
Acta Neurobiologiae Experimentalis , ISSUE 1, 1–19
Hardness is a measure of the amount of calcium and magnesium salt that is present in water. In general, surface water is characterized by lower hardness than groundwater. Water with a hardness of up to 100 mgCaCO3/L is regarded as very soft, between 100 and 200 mgCaCO3/L as soft, between 200 and 350 mgCaCO3/L as medium-hard, between 350 and 550 mgCaCO3/L as hard and above 550 mgCaCO3/L as very hard .
The effluents from urban wastewater treatment plant may be characterized by
Architecture, Civil Engineering, Environment , ISSUE 2, 141–147