review-article
antiepileptic drugs (AEDs) was based on the avoidance of combined pharmacodynamic or pharmacokinetic side effects (French and Faught, 2009).
In the ninth decade of the twentieth century, the so-called second-generation antiepileptic drugs (SGAEDs) started being commercialized. They had the advantages of better pharmacokinetic and pharmacodynamic profiles, less side effects and fewer drug interactions when compared with their first generation counterparts. Furthermore, several of them had novel mechanisms of
José Pimentel,
José Manuel Lopes Lima
Journal of Epileptology, Volume 27 , 27–34
Review Paper
Magdalena Chrościńska-Krawczyk,
Magdalena Wałek,
Bożydar Tylus,
Stanisław J. Czuczwar
Journal of Epileptology, Volume 22 , ISSUE 1, 37–50
Article
Magdalena Skarżyńska,
Magdalena Zając,
Dariusz Wasyl
Postępy Mikrobiologii - Advancements of Microbiology, Volume 59 , ISSUE 1, 49–62
research-article
it could depend on progesterone metabolites, such as estrogen, androgen, and allopregnanolone on estrogen, androgen, and GABAA receptors, respectively. Therefore, further research is necessary to better clarify the molecular mechanisms on the basis of progesterone action on object memory consolidation.
Fig. 2.
Action of female hormones in the central nervous system. Genomic (or classical) and non-genomic (or non-classical) mechanisms of action of estrogens and progesterone.
Role of androgens
Assunta Pompili,
Carla Iorio,
Antonella Gasbarri
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 117–128
Mini Review
The growing resistance of microorganisms towards antibiotics has become a serious global problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are urgently needed to combat infections caused by multidrug resistant pathogens, including bacteria, fungi and viruses. Development of novel antimicrobial agents is still highly dependent on the discovery of new natural products. At present, most antimicrobial drugs used in medicine are of natural origin. Among the natural
KATARZYNA JAKUBIEC-KRZESNIAK,
ALEKSANDRA RAJNISZ-MATEUSIAK,
ADAM GUSPIEL,
JOANNA ZIEMSKA,
JOLANTA SOLECKA
Polish Journal of Microbiology, Volume 67 , ISSUE 3, 259–272
research-article
or corticosterone), which in excess leads to CNS degeneration and neurogenesis inhibition. This results in damage to a structure playing a vital role in mood regulation. The study also confirmed the antidepressant efficacy of VOR, DAP, and combination of these drugs in the group of stressed animals. Because of the study drugs’ mechanisms of action, special care should be taken when combining them in therapy as such combination if uncontrolled may lead to several dangerous drug interactions and
Piotr Ratajczak,
Krzysztof Kus,
Małgorzata Zielińska-Przyjemska,
Beata Skórczewska,
Tomasz Zaprutko,
Dorota Kopciuch,
Anna Paczkowska,
Elżbieta Nowakowska
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 217–224
Review Paper
Background. Biofeedback methods represent side effect free complementary options in the treatment of epilepsy. In this paper we review the current status of these methods in terms of clinical study results and their evaluation by systematic review papers. Possible mechanisms of action in biofeedback methods are discussed. Aim. To present the current status of biofeedback methods applied to patients with epilepsy. Material and Methods. With a literature search up to 10/2016 we screened
Carmen Uhlmann,
Walter Fröscher
Journal of Epileptology, Volume 24 , ISSUE 2, 173–180
research-paper
which may affect the therapy’s efficacy.
CONCLUSION
Moreover, analysis of the pathomechanism of depression and the mechanisms of action of individual drugs allows for the assumption that the combined administration of the tested drugs (particularly DAP) may be effective in the treatment of depressive and anxiety disorders, although possible negative interactions between treatment drugs must always be assessed for. Lastly, the results also showed that the antidepressant efficacy of VOR and FLU are
Piotr Ratajczak,
Krzysztof Kus,
Tomasz Zaprutko,
Mikołaj Szczepański,
Sandra Rusowicz,
Elżbieta Nowakowska
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 13–24
Research paper
Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone. Antinociceptive activity was assessed by the formalin test in male Wistar rats (200–250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related
Katarina Savić Vujović,
Sonja Vučković,
Dolika Vasović,
Branislava Medić,
Nick Knežević,
Milica Prostran
Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 2, 137–146
Review
receptors (GPCRs), provide hope for future treatments of this type of hereditary motor and sensory neuropathy. A review of mechanisms of action of several compounds tested for CMT1A in pre-clinical and clinical studies ascorbic acid, onapristone, PXT3003 (baclofen, naltrexone, and sorbitol), and ADX71441, very clearly indicates an important role for adenylyl cyclase activity and GPCRs in the pathomechanism of the disease. Metabotropic γ-aminobutyric acid receptors (GABABR), subtype mu (μ) opioid
Artur J. Kiepura,
Andrzej Kochański
Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 198–209
Article
Anna Majewska,
Beata Młynarczyk-Bonikowska,
Magdalena Malejczyk,
Sławomir Majewski,
Grażyna Młynarczyk
Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 291–299