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review-article

Rational polytherapy: Myth or reality?

antiepileptic drugs (AEDs) was based on the avoidance of combined pharmacodynamic or pharmacokinetic side effects (French and Faught, 2009). In the ninth decade of the twentieth century, the so-called second-generation antiepileptic drugs (SGAEDs) started being commercialized. They had the advantages of better pharmacokinetic and pharmacodynamic profiles, less side effects and fewer drug interactions when compared with their first generation counterparts. Furthermore, several of them had novel mechanisms of

José Pimentel, José Manuel Lopes Lima

Journal of Epileptology, Volume 27 , 27–34

Review Paper

Selected classical and novel antiepileptic drugs – mechanisms of action, neuroprotection, and effectiveness in epileptic and non-epileptic conditions

Magdalena Chrościńska-Krawczyk, Magdalena Wałek, Bożydar Tylus, Stanisław J. Czuczwar

Journal of Epileptology, Volume 22 , ISSUE 1, 37–50

Article

ANTIBIOTICS AND BACTERIA: MECHANISMS OF ACTION AND RESISTANCE STRATEGIES

Magdalena Skarżyńska, Magdalena Zając, Dariusz Wasyl

Postępy Mikrobiologii - Advancements of Microbiology, Volume 59 , ISSUE 1, 49–62

research-article

Effects of sex steroid hormones on memory

it could depend on progesterone metabolites, such as estrogen, androgen, and allopregnanolone on estrogen, androgen, and GABAA receptors, respectively. Therefore, further research is necessary to better clarify the molecular mechanisms on the basis of progesterone action on object memory consolidation. Fig. 2. Action of female hormones in the central nervous system. Genomic (or classical) and non-genomic (or non-classical) mechanisms of action of estrogens and progesterone. Role of androgens

Assunta Pompili, Carla Iorio, Antonella Gasbarri

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 117–128

Mini Review

Secondary Metabolites of Actinomycetes and their Antibacterial, Antifungal and Antiviral Properties

The growing resistance of microorganisms towards antibiotics has become a serious global problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are urgently needed to combat infections caused by multidrug resistant pathogens, including bacteria, fungi and viruses. Development of novel antimicrobial agents is still highly dependent on the discovery of new natural products. At present, most antimicrobial drugs used in medicine are of natural origin. Among the natural

KATARZYNA JAKUBIEC-KRZESNIAK, ALEKSANDRA RAJNISZ-MATEUSIAK, ADAM GUSPIEL, JOANNA ZIEMSKA, JOLANTA SOLECKA

Polish Journal of Microbiology, Volume 67 , ISSUE 3, 259–272

research-article

Antistress and antidepressant properties of dapoxetine and vortioxetine

or corticosterone), which in excess leads to CNS degeneration and neurogenesis inhibition. This results in damage to a structure playing a vital role in mood regulation. The study also confirmed the antidepressant efficacy of VOR, DAP, and combination of these drugs in the group of stressed animals. Because of the study drugs’ mechanisms of action, special care should be taken when combining them in therapy as such combination if uncontrolled may lead to several dangerous drug interactions and

Piotr Ratajczak, Krzysztof Kus, Małgorzata Zielińska-Przyjemska, Beata Skórczewska, Tomasz Zaprutko, Dorota Kopciuch, Anna Paczkowska, Elżbieta Nowakowska

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 217–224

Review Paper

Biofeedback as complementary treatment in patients with epilepsy – an underestimated therapeutic option? Review, results, discussion

Background. Biofeedback methods represent side effect free complementary options in the treatment of epilepsy. In this paper we review the current status of these methods in terms of clinical study results and their evaluation by systematic review papers. Possible mechanisms of action in biofeedback methods are discussed. Aim. To present the current status of biofeedback methods applied to patients with epilepsy. Material and Methods. With a literature search up to 10/2016 we screened

Carmen Uhlmann, Walter Fröscher

Journal of Epileptology, Volume 24 , ISSUE 2, 173–180

research-paper

Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats

which may affect the therapy’s efficacy. CONCLUSION Moreover, analysis of the pathomechanism of depression and the mechanisms of action of individual drugs allows for the assumption that the combined administration of the tested drugs (particularly DAP) may be effective in the treatment of depressive and anxiety disorders, although possible negative interactions between treatment drugs must always be assessed for. Lastly, the results also showed that the antidepressant efficacy of VOR and FLU are

Piotr Ratajczak, Krzysztof Kus, Tomasz Zaprutko, Mikołaj Szczepański, Sandra Rusowicz, Elżbieta Nowakowska

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 13–24

Research paper

Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test

Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone. Antinociceptive activity was assessed by the formalin test in male Wistar rats (200–250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related

Katarina Savić Vujović, Sonja Vučković, Dolika Vasović, Branislava Medić, Nick Knežević, Milica Prostran

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 2, 137–146

Review

Charcot-Marie-Tooth type 1A drug therapies: role of adenylyl cyclase activity and G-protein coupled receptors in disease pathomechanism

receptors (GPCRs), provide hope for future treatments of this type of hereditary motor and sensory neuropathy. A review of mechanisms of action of several compounds tested for CMT1A in pre-clinical and clinical studies ascorbic acid, onapristone, PXT3003 (baclofen, naltrexone, and sorbitol), and ADX71441, very clearly indicates an important role for adenylyl cyclase activity and GPCRs in the pathomechanism of the disease. Metabotropic γ-aminobutyric acid receptors (GABABR), subtype mu (μ) opioid

Artur J. Kiepura, Andrzej Kochański

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 198–209

Article

POSSIBILITIES OF PREVENTION AND TREATMENT OF HUMAN CYTOMEGALOVIRUS INFECTIONS INCLUDING NEW DRUGS AND COMPOUNDS WITH POTENTIAL APPLICATION

Anna Majewska, Beata Młynarczyk-Bonikowska, Magdalena Malejczyk, Sławomir Majewski, Grażyna Młynarczyk

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 291–299

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