antiepileptic drugs (AEDs) was based on the avoidance of combined pharmacodynamic or pharmacokinetic side effects (French and Faught, 2009).
In the ninth decade of the twentieth century, the so-called second-generation antiepileptic drugs (SGAEDs) started being commercialized. They had the advantages of better pharmacokinetic and pharmacodynamic profiles, less side effects and fewer drug interactions when compared with their first generation counterparts. Furthermore, several of them had novel mechanisms of
José Manuel Lopes Lima
Journal of Epileptology, Volume 27 , 27–34
Stanisław J. Czuczwar
Journal of Epileptology, Volume 22 , ISSUE 1, 37–50
Postępy Mikrobiologii - Advancements of Microbiology, Volume 59 , ISSUE 1, 49–62
it could depend on progesterone metabolites, such as estrogen, androgen, and allopregnanolone on estrogen, androgen, and GABAA receptors, respectively. Therefore, further research is necessary to better clarify the molecular mechanisms on the basis of progesterone action on object memory consolidation.
Action of female hormones in the central nervous system. Genomic (or classical) and non-genomic (or non-classical) mechanisms of action of estrogens and progesterone.
Role of androgens
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 117–128
The growing resistance of microorganisms towards antibiotics has become a serious global problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are urgently needed to combat infections caused by multidrug resistant pathogens, including bacteria, fungi and viruses. Development of novel antimicrobial agents is still highly dependent on the discovery of new natural products. At present, most antimicrobial drugs used in medicine are of natural origin. Among the natural
Polish Journal of Microbiology, Volume 67 , ISSUE 3, 259–272
or corticosterone), which in excess leads to CNS degeneration and neurogenesis inhibition. This results in damage to a structure playing a vital role in mood regulation. The study also confirmed the antidepressant efficacy of VOR, DAP, and combination of these drugs in the group of stressed animals. Because of the study drugs’ mechanisms of action, special care should be taken when combining them in therapy as such combination if uncontrolled may lead to several dangerous drug interactions and
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 217–224
Background. Biofeedback methods represent side effect free complementary options in the treatment of epilepsy. In this paper we review the current status of these methods in terms of clinical study results and their evaluation by systematic review papers. Possible mechanisms of action in biofeedback methods are discussed. Aim. To present the current status of biofeedback methods applied to patients with epilepsy. Material and Methods. With a literature search up to 10/2016 we screened
Journal of Epileptology, Volume 24 , ISSUE 2, 173–180
which may affect the therapy’s efficacy.
Moreover, analysis of the pathomechanism of depression and the mechanisms of action of individual drugs allows for the assumption that the combined administration of the tested drugs (particularly DAP) may be effective in the treatment of depressive and anxiety disorders, although possible negative interactions between treatment drugs must always be assessed for. Lastly, the results also showed that the antidepressant efficacy of VOR and FLU are
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 13–24
Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone. Antinociceptive activity was assessed by the formalin test in male Wistar rats (200–250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related
Katarina Savić Vujović,
Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 2, 137–146
receptors (GPCRs), provide hope for future treatments of this type of hereditary motor and sensory neuropathy. A review of mechanisms of action of several compounds tested for CMT1A in pre-clinical and clinical studies ascorbic acid, onapristone, PXT3003 (baclofen, naltrexone, and sorbitol), and ADX71441, very clearly indicates an important role for adenylyl cyclase activity and GPCRs in the pathomechanism of the disease. Metabotropic γ-aminobutyric acid receptors (GABABR), subtype mu (μ) opioid
Artur J. Kiepura,
Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 198–209
Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 291–299