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Hypothesis | 30-August-2017

Do minocycline and other suppressors of microglia reactivity have a future in prevention or treatment of epilepsy?

potential usefulness of microglia regulators and anti-inflammatory agents in designing antiepileptic/antiepileptogenic drugs, with the primary mechanism of action based on the inhibition of neuroinflammation. Methods. We reviewed PubMed and MEDLINE databases to select publications in the topic: epilepsy, neuroinflammation, microglia and microglia regulators with antiepileptic properties. We searched the databases up to April 2017 with no date restrictions. Review and Discussion. In the present paper, we

Władysław Lasoń, Joanna Ślusarczyk, Magdalena Regulska, Monika Leśkiewicz, Agnieszka Basta-Kaim

Journal of Epileptology, Volume 25 , ISSUE 1-2, 9–20

research-paper | 30-November-2020

An Aβ3-10-KLH vaccine decreases Aβ plaques and astrocytes and microglia activation in the brain of APP/PS1 transgenic mice

necrosis factor (TNF)-α, and reactive oxygen species (ROS) that lead to neuroinflammation and neuron death (Heneka et al., 2015a; 2015b; Flores et al., 2018). The selective inhibition of the chemokine receptor CX3CR1 in the brain can modulate the phagocytosis of microglia and the degradation of Aβ plaques (Liu et al., 2010). Plaque-associated microglia express known myeloid markers shared among macrophage progeny, microglia, and peripheral monocytes, including CD45, Iba1, and CD11b (Bennett et al

Yang Wang, Bing Xu, Jin Zhou, Jinchun Wang, Guoqing Wang, Yunpeng Cao

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 207–217

Research paper | 06-February-2018

Energy-dense diet triggers changes in gut microbiota, reorganization of gut-brain vagal communication and increases body fat accumulation

alter vagal gut-brain communication associated with increased body fat accumulation. Sprague-Dawley rats consumed a low energy-dense rodent diet (LFD; 3.1 kcal/g) or high energy-dense diet (HFD, 5.24 kcal/g). Minocycline was used to manipulate gut microbiota composition. 16S Sequencing was used to determine microbiota composition. Immunofluorescence against IB4 and Iba1 was used to determine NTS reorganization and microglia activation. Nodose ganglia from LFD rats were isolated and co-cultured with

Alexandra C. Vaughn, Erin M. Cooper, Patricia M. DiLorenzo, Levi J. O’Loughlin, Michael E. Konkel, James H. Peters, Andras Hajnal, Tanusree Sen, Sun Hye Lee, Claire B. de La Serre, Krzysztof Czaja

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 18–30

research-article | 30-November-2019

Roux-en-Y gastric bypass surgery triggers rapid DNA fragmentation in vagal afferent neurons in rats

., 2011). Previous studies from our laboratory have revealed that subdiaphragmatic vagotomy triggers transient withdrawal and remodeling of central vagal afferent terminals in the NTS observed ten days post-surgery (Peters et al., 2013). Moreover, Ballsmider et al. (2015) showed that ten days after RYGB surgery the density of vagal afferents is dramatically reduced and microglia activation is significantly increased in the NTS. Furthermore, 14 days following subdiapgragmatic vagotomy, we observed

Dulce M. Minaya, Patricia M. Di Lorenzo, Andras Hajnal, Krzysztof Czaja

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 432–444

Research paper | 31-July-2017

Upregulation of CCL3/MIP‑1alpha regulated by MAPKs and NF‑kappaB mediates microglial inflammatory response in LPS‑induced brain injury

and phosphorylation of MAPKs in the brains of rats 6, 24, and 72 h after LPS administration. Additionally, LPS‑treated rats were administered an anti‑MIP‑1alpha neutralizing antibody, and the microglial reaction and the expression of both cyclooxygenase‑2 and inducible nitric oxide synthase (iNOS) were analyzed. We finally evaluated the effect of an inhibitor of P38 MAPK, an inhibitor of ERK1/2, or an inhibitor of NF‑kappaB, on the levels of CCL3/MIP‑1alpha protein and numbers of microglia in the

Xiaobo Zhu, Dee Wei, Ou Chen, Zhaohua Zhang, Jiang Xue, Shanying Huang, Weiwei Zhu, Yibiao Wang

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 304–317

Review | 18-May-2018

MeCP2 in central nervous system glial cells: current updates

have discussed the role of MeCP2 in glial subtypes, astrocytes, oligodendrocytes and microglia, and how loss of MeCP2 function in these cells has a profound influence on both glial and neuronal function.

Kedarlal Sharma, Juhi Singh, Emma E. Frost, Prakash P. Pillai

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 1, 30–40

Research paper | 04-May-2018

Axonal outgrowth stimulation after alginate/mesenchymal stem cell therapy in injured rat spinal cord

axonal growth (GAP-43 expression) and both microglia (Iba-1) and astrocyte (GFAP) reactions at the lesion site and in the segments below and above the lesion. To detect functional improvement, during whole survival period we performed behavioral analyses of locomotor abilities using a classical open field test (BBB score) and a Catwalk automated gait analyzing device (Noldus). We found that despite the absence of locomotor improvement, application of both alginate and MSCs caused significant increase

Juraj Blaško, Eva Szekiova, Lucia Slovinska, Jozef Kafka, Dasa Cizkova

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 337–350

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