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Research paper | 25-July-2017

Chronotype and sleep quality as a subphenotype in association studies of clock genes in mood disorders

Genetic background and clinical picture of mood disorders (MD) are complex and may depend on many genes and their potential interactions as well as environmental factors. Therefore, clinical variations, or endophenotypes, were suggested for association studies. The aim of the study was to investigate association between the chronotype (CH) and quality of sleep characteristics with polymorphisms CLOCK, ARNTL, TIMELESS and PER3 genes in MD. We included a total sample of 111 inpatients and 126

Monika Dmitrzak-Węglarz, Joanna Pawlak, Monika Wiłkość, Izabela Miechowicz, Małgorzata Maciukiewicz, Wanda Ciarkowska, Dorota Zaremba, Joanna Hauser

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 32–42

Review | 25-July-2017

Lithium – therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms

Mood disorders are relatively common serious human diseases for which there is often no ideal pharmacotherapy. Basic characteristic of these diseases is affective disorder shifting the mood of the patient to depression (together with anxiety or not) or towards to euphoria. Available drugs are usually divided into two groups – mood stabilizers, which are used primarily to treat bipolar disorder,and antidepressants for the treatment of unipolar depression. Lithium is still recommended as the

Miroslava Vosahlikova, Petr Svoboda

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 1–19

research-article | 15-October-2020

Subchronic effects of ligands of cannabinoid receptors on learning and memory processes of olfactory bulbectomized rats

INTRODUCTION Endocannabinoid system (ECS) plays role in many physiological processes, including mood, learning and memory. It is also involved in the pathogenesis of anxiety and mood disorders, as well as neurodegenerative disorders (Hill and Gorzalka, 2009; Ranieri et al., 2016). ECS consists of the endogenous cannabinoids (endocannabinoids), cannabinoid receptors and the enzymes that synthesize and degrade endocannabinoids. The cannabinoid receptors (CB1 and CB2) belong to the class of G

Margarita Velikova, Dobrinka Doncheva, Roman Tashev

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 286–296

research-article | 30-November-2019

Effects of HTR1A rs6295 polymorphism on emotional attentional blink

mood disorders. Behavioral control and regulation of affect depend on gene-environment interactions and encompass both cortical and subcortical structures where genetic variance is expressed (Todd et al., 2013; Markovic et al., 2014; Hibar et al., 2015; Bogdan et al., 2016; Xu et al., 2017). Monoaminergic brain systems, including the serotonin neurotransmission and -modulation systems, are known to be implicated in anxiety-and mood disorders such as depression, and associated with common genetic

Kadi Tulver, Madis Bachmann, Mariliis Vaht, Jaanus Harro, Talis Bachmann

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 389–399

research-article | 30-November-2020

Psychiatric morbidity in children and adolescents with dermatological disorders

4.0 Others (acute/transient conditions) 6 2.4 Genetic dermatoses 3 1.2 Total 251 100 The rates of general psychiatric comorbidity, mood disorders, anxiety disorders and adjustment disorders were significantly higher in the study group than in the control group (psychiatric comorbidity: χ2 = 29.8, p = 0.0001; mood disorders: χ2 = 11.14, p = 0.001; anxiety disorders: χ2 = 11.54, p = 0.001; adjustment disorder: χ2 = 30.77, p = 0.0001). There was no significant difference between the groups

Dilşad Yıldız Miniksar, Özlem Özel Özcan, Hülya Cenk, Yelda Kapıcıoğlu, Ayşegül Polat

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 1–8

Research Article | 05-July-2017

Low self-esteem and high psychological distress are common among depressed adolescents presenting to the Pediatric Emergency Department

alcohol level.Conclusions:Our findings underscore the importance of identifying mood disorders, suicidality, and self-esteem among adolescents with acute alcohol intoxication at the PED. Intensive psychiatric evaluation in an emergency department is necessary in order to detect those adolescents requiring additional treatment and support.

Varpu Puuskari, Terhi Aalto-Setälä, Erkki Komulainen, Mauri Marttunen

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 5 , ISSUE 1, 39–49

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