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research-article

Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure

). Rat model data remains inconclusive regarding methadone effects on myelination. Rat pups with antenatal exposure to methadone via an osmotic minipump implanted in the pregnant dam demonstrated an up-regulation of myelin production and altered structure (Vestal-Laborde et al., 2014). Alternatively, rat pups with antenatal exposure to methadone via drinking water demonstrated decreased expression of myelin-specific proteins (Gourevitch et al., 2016). Detoxification during pregnancy has been

Rahul Oberoi, Tianci Chu, Nicholas Mellen, Rekha Jagadapillai, Hezhong Ouyang, Lori A. Devlin, Jun Cai

Acta Neurobiologiae Experimentalis , ISSUE 4, 367–373

Case report

Central Pontine Myelinolysis

, dysarthria, diplopia and acute para/quadraparesis. Patients can also experience locked in syndrome, where cognitive function is intact but all muscles are paralysed with the exception of eye blinking. CPM gets its name as it occurs when cell dysfunction causes destruction of the myelin sheath of nerve cells in the brain stem, more specifically the pons. It is associated with poor prognosis and prevention is of primary importance. Freddy is a 35 year old freelance graphic designer, fitness

Leigh Arrowsmith, Christopher Tolar

Australasian Journal of Neuroscience , ISSUE 1, 15–19

Research paper

Rat white matter injury model induced by endothelin-1 injection: technical modification and pathological evaluation

function deficit appeared temporarily after the operation. Histological studies confirmed damage of axons and myelin sheaths followed by inflammatory reaction and gliosis similar to lacunar infarction, with lesion volume of less than 1% of the whole brain. Hydroxystilbamidine injected into the lesion revealed wide spatial distribution of the affected neuronal population. Compared with prior ET 1 injection models, this method induced standardized amount of white matter damage and temporary motor

Hideaki Ono, Hideaki Imai, Satoru Miyawaki, Hirofumi Nakatomi, Nobuhito Saito

Acta Neurobiologiae Experimentalis , ISSUE 3, 212–224

Review

Charcot-Marie-Tooth type 1A drug therapies: role of adenylyl cyclase activity and G-protein coupled receptors in disease pathomechanism

) and cAMP signaling. This review endeavors to outline a pathway leading inversely from therapy to an indispensable role for adenylyl cyclase activity and GPCRs in the modulation of dosage sensitive peripheral myelin protein (PMP22) gene expression.

Artur J. Kiepura, Andrzej Kochański

Acta Neurobiologiae Experimentalis , ISSUE 3, 198–209

Research paper

Effects of epidural compression on stellate neurons and thalamocortical afferent fibers in the rat primary somatosensory cortex

-lesion. Anterograde tracing analyses exhibited a progressive decline of TCA fiber density in barrel field for 6 months post-lesion. Due to the abrupt decrease of TCA fiber density at 3 days after compression, we further used electron microscopy to investigate the ultrastructure of TCA fibers at this time. Some TCA fiber terminal profiles with dissolved or darkened mitochondria and fewer synaptic vesicles were distorted and broken. Furthermore, the disruption of mitochondria and myelin sheath was

Tzu-Yin Yeh, Guo-Fang Tseng, Chi-Yu Tseng, Yung-Hsin Huang, Pei-Hsin Liu

Acta Neurobiologiae Experimentalis , ISSUE 1, 1–17

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