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Clinical Practice

Toward a new generation of quality registries for neurodevelopmental disorders: the example of NEUROPSYK

Swedish healthcare quality registries are tools for the evaluation and improvement of clinical services and population-based research. There are presently 11 national quality registries that focus on psychiatric disorders; but none cover all neurodevelopmental disorders (NDDs) as defined by the International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Health care

Anna Löfgren Wilteus, Frida Bartonek, Jacqueline Borg, Sven Bölte

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 3, 141–146

Research Article

Collection of developmental history in the evaluation of schizophrenia spectrum disorders

Schizophrenia is a heterogeneous disorder that is characterized by varying levels of hallucinations, delusions, negative symptoms, and disorganized features. The presence and severity of neurodevelopmental precursors and premorbid psychopathology also vary among individuals. To fully understand individual patients and to sort out phenotypic heterogeneity for genetic research studies, instruments designed to collect developmental history relevant to schizophrenia may be helpful.The goal was to

Angela M. Reiersen

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 1, 36–43

Editorial

How should we classify complex neurodevelopmental disorders?

Angela M. Reiersen

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 1, 1–2

Review

Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males

The prevalence of neurodevelopmental disorders (NDs), including autism spectrum disorder, attention-deficit/hyperactivity disorder, tic disorder, obsessive-compulsive disorder, and emotional disturbances, has increased notably in the past few decades. To date, debate continues as to the origins of NDs. Increases in widespread exposure to and bioaccumulation of chemical neurotoxicants have paralleled the upsurge in NDs, and are suggested to be causal agents for NDs. One consistent aspect of NDs

Janet K. Kern, David A. Geier, Kristin G. Homme, Paul G. King, Geir Bjørklund, Salvatore Chirumbolo, Mark R. Geier

Acta Neurobiologiae Experimentalis , ISSUE 4, 269–296

research-article

A ten year longitudinal examination of the incidence rate and age of childhood encephalopathy diagnoses in an autism spectrum disorder diagnosed cohort

Janet K. Kern, David A. Geier, Kristin G. Homme, Mark R. Geier

Acta Neurobiologiae Experimentalis , ISSUE 1, 66–75

Review

MeCP2 in central nervous system glial cells: current updates

Methyl-CpG binding protein 2 (MeCP2) is an epigenetic regulator, which preferentially binds to methylated CpG dinucleotides in DNA. MeCP2 mutations have been linked to Rett syndrome, a neurodevelopmental disorder characterized by severe intellectual disability in females. Earlier studies indicated that loss of MeCP2 function in neuronal cells was the sole cause of Rett syndrome. Subsequent studies have linked MeCP2 expression in CNS glial cells to Rett syndrome pathogenesis. In this review, we

Kedarlal Sharma, Juhi Singh, Emma E. Frost, Prakash P. Pillai

Acta Neurobiologiae Experimentalis , ISSUE 1, 30–40

research-paper

Autism spectrum disorder and mercury toxicity: use of genomic and epigenetic methods to solve the etiologic puzzle

INTRODUCTION Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental condition of unknown etiology. Importantly, reported manifestations of low-level exposure to mercury, a highly neurotoxic heavy metal, are similar to those of ASD. In the past several years, evidence has accumulated linking the risk of toxic manifestations of low-level mercury exposure to particular genes, mutations, and epigenetic changes. The fields of genomics, genetics, and epigenetics are rapidly

Mark E. McCaulley

Acta Neurobiologiae Experimentalis , ISSUE 2, 113–125

Review

Immune dysfunction and neuroinflammation in autism spectrum disorder

Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder with a complex pathogenesis. Many studies over the last four decades have recognized altered immune responses among individuals diagnosed with ASD. The purpose of this critical and comprehensive review is to examine the hypothesis that immune dysfunction is frequently present in those with ASD. It was found that often individuals diagnosed with ASD have alterations in immune cells such as T cells, B cells

Geir Bjørklund, Khaled Saad, Salvatore Chirumbolo, Janet K. Kern, David A. Geier, Mark R. Geier, Mauricio A. Urbina

Acta Neurobiologiae Experimentalis , ISSUE 4, 257–268

research-article

Putative shared mechanisms in autism spectrum disorders and attention deficit hyperactivity disorder, a systematic review of the role of oxidative stress

INTRODUCTION Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders characterized by impairments in communication and in reciprocal social interaction along with restrictive and repetitive behaviours (American Psychiatric Association, 2013). Questions regarding the etiopathological mechanism of this complex disorder remain unanswered (Lai et al., 2014; Happe et al., 2006; Antshel and Russo, 2019). Attention deficit hyperactivity disorder (ADHD) is a frequent

Filipa Sa-Carneiro, Conceição Calhau, Rui Coelho, Margarida Figueiredo-Braga

Acta Neurobiologiae Experimentalis , ISSUE 2, 129–138

Research paper

Face processing in a case of high functioning autism with developmental prosopagnosia

perception and recognition, thus creating a unique neurodevelopmental condition. We used eye-tracking and functional magnetic resonance imaging (fMRI) method. Eye-tracking and fMRI results of PK were compared to results of control subjects. Patient PK showed atypical gaze-fixation strategy during face perception and typical patterns of brain activations in the FG and OFA. However, a significant difference between PK and control subjects was found in the left anterior superior temporal sulcus/middle

Hanna B. Cygan, Hanna Okuniewska, Katarzyna Jednoróg, Artur Marchewka, Marek Wypych, Anna Nowicka

Acta Neurobiologiae Experimentalis , ISSUE 2, 114–131

Research Article

A multicenter, randomized, controlled study of Training Executive, Attention, and Motor Skills (TEAMS) in Danish preschool children with attention-deficit/hyperactivity disorder: Rationale and description of the intervention and study protocol

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder that is often detected during the preschool years. Neuroimaging data indicate that children with ADHD have brains that are characterized by growth and functional anomalies. Data suggest that the diminution of ADHD symptoms is correlated with improved neural functioning and growth. On the basis of these findings, interventions that target neural growth, which indicates neural development, can

Helle Annette Vibholm, Jesper Pedersen, Anne Holm, Søren Krue

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , ISSUE 1, 2–10

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