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Review Paper | 10-December-2015

Antiepileptic drugs as a new therapeutic concept for the prevention of cognitive impairment and Alzheimer’s disease. Recent advances

Introduction. Excessive accumulation of amyloid-beta (A_) peptides in the brain results initially in mild cognitive impairment (MCI) and finally in Alzheimer’s disease (AD). Evidences from experimental and clinical studies show that pathological hyperexcitability of hippocampal neurons is a very early functional impairment observed in progressive memory dysfunctions. Therefore, antiepileptic drugs (AEDs) whose mechanism of action is aimed at inhibition of such neuronal hyperexcitability

Krzysztof Sendrowski, Wojciech Sobaniec

Journal of Epileptology, Volume 23 , ISSUE 2, 139–147

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