., 2016). Stroke is often due to a transient or permanent reduction of cerebral blood flow. Many studies have been designed in an attempt to find a neuroprotective strategy for the prevention and treatment of ischemic brain injury. Currently, administration of thrombolytic drugs, to restore blood flow, is the most common approach in cases of ischemic brain injury. However, restoration of blood flow due to spontaneous reperfusion or thrombolytic therapy results in the production of reactive oxygen
Sayed Masoud Hosseini,
Hamid Gholami Pourbadie,
Acta Neurobiologiae Experimentalis , ISSUE 1, 73–85
(tPA), a thrombolytic agent that targets the thrombus within the blood vessel.
Neuroprotection remains one of the holy grails of AIS therapy. The ability to protect the ischemic brain from injury until reperfusion and also protect the brain from reperfusion injury could theoretically prevent disability in stroke survivors (Patel and McMullen, 2017). In the past, many neuroprotective agents showed efficacy in a variety of animal models of stroke, including 5-HT1A agonists, free radical scavengers
Siti Norsyafika Kamarudin,
Nafeeza Mohd Ismail
Acta Neurobiologiae Experimentalis , ISSUE 1, 1–18
et al., 2005; Yousefsani et al., 2018). Crocin is the constituent that is the main cause of the color of saffron (Lee et al., 2005, Chen et al., 2008, Khalili et al., 2010). Crocin has been shown to act as an antioxidant (Chen et al., 2008; Mard et al., 2016) and a neuroprotective agent (Mehri et al., 2012). The antioxidant function of crocin is linked to the sugar moiety in the crocin molecule, which plays a key role in its chemical reactivity (Chen et al., 2008). In addition, crocin has
Sara Yousefi Moghadam,
Mobina Abbasi Mesrabadi
Acta Neurobiologiae Experimentalis , ISSUE 4, 352–366
Filiz Civil Arslan,
İlkay Keleş Altun,
Acta Neurobiologiae Experimentalis , ISSUE 3, 192–198
Introduction. One of the most common neurological disorders is epilepsy, characterised by recurrent spontaneus seizures. Although not fully efficient in ca 30% of patients, pharmacologic treatment of epilepsy plays an important therapeutic approach not only against epilepsy. Aim. To provide data on the mechanism of action, activity and neuroprotective efficacy in experimental conditions, clinical efficacy against epilepsy and non-epileptic diseases of major, classical and newer antiepileptic
Stanisław J. Czuczwar
Journal of Epileptology , ISSUE 1, 37–50
neuroprotective effects of BKCa channel modulators. Using organotypic hippocampal slice cultures exposed to glutamate, we demonstrated that preincubation of the slices with the BKCa channel opener NS1619 resulted in decreased neuronal cell death measured as reduced uptake of propidium iodide. This neuroprotective effect was reversed by preincubation with the BKCa channel inhibitors paxilline and Iberiotoxin (IbTx). Moreover, mitochondrial respiration measurements revealed that NS1619 induced an
Ulrich H. Schröder,
Klaus G. Reymann,
Acta Neurobiologiae Experimentalis , ISSUE 1, 20–31
inhibitor, has various pharmacological actions, including lowering cholesterol and reducing inflammation, as well as anticancer, antioxidant and, in particular, neuroprotective effects (Nasiri et al., 2016; Yan et al., 2015). This drug has shown neuroprotective activity and easily permeates the blood-brain barrier because of its lipophilicity (Lin et al., 2015). Statins alter the fate of neural stem-progenitor cells (NSPCs) in different ways and during differentiation may lead to the expression of mRNAs
Iraj Jafari Anarkooli,
Acta Neurobiologiae Experimentalis , ISSUE 4, 413–420
Parkinson’s disease (PD) is a common neurodegenerative disorder, resulting from progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Neuroprotective therapies in PD are still not available, perhaps because animal models do not imitate the chronic and progressive nature of the clinical state of PD. To address this, we performed a feasibility study aimed at establishing a chronic non-primate large animal PD model in Göttingen minipigs based on continuous infusion
Mette Slot Nielsen,
Andreas Nørgaard Glud,
Jens Christian Sørensen,
Carsten Reidies Bjarkam
Acta Neurobiologiae Experimentalis , ISSUE 3, 199–211
were compared to the action of PACAP38, a neuropeptide with well known BDNF-mediated neuroprotective effects. The tested neuroleptics differentially regulated the mRNA expression and protein level of BDNF depending on the concentration and incubation time. Using rtPCR technique, we demonstrate that, from the three tested neuroleptics, both haloperidol as well as olanzapine at 5 μM concentration (but not at 20 μM) increased BDNF mRNA expression with a similar efficacy after a 72 h incubation. In
Acta Neurobiologiae Experimentalis , ISSUE 3, 205–213
anti-inflammatory agent, and also anti-inflammatory, neuroprotective, antioxidant and antiapoptotic properties of minocycline. Futhermore, the basics of demeclocycline application in the treatment of inappropriate antidiuretic hormone hypesecretion syndrome and rifaximin use as an anti-inflammatory and eubiotic agent are presented. Neuroprotective action of ceftriaxone and anti-inflammatory and immunostimulatory action of fusafungine were also described.
Postępy Mikrobiologii - Advancements of Microbiology , ISSUE 4, 301–312
minimal functional improvement. Other neuroprotective strategies such as therapeutic hypothermia alone or in combination with other interventions, whose mechanisms of action are multifactorial and may thereby protect nervous tissue and minimize overall loss of neurological function, are therefore being considered for experimental and clinical trials.
Experimental animals used in SCI studies
Although detailed descriptions of the causes and symptoms of traumatic SCI date back to ancient Egyptian times
Acta Neurobiologiae Experimentalis , ISSUE 2, 172–178
for neuroscientists and neurologists (Dietrich, 2015; Yuan et al., 2019).
Many different strategies have been tried to find efficacious treatments for SCI. In this context, it has been shown that stem cells hold great promise for the treatment of SCI due to their neuroprotective and neuroregenerative properties (Gazdic et al., 2018; Mukhamedshina et al., 2019).
For example, embryonic stem cells, adult stem cells such as neural stem cells, mesenchymal stem cells and induced pluripotent stem cells
Acta Neurobiologiae Experimentalis , ISSUE 4, 319–327
the removal of dysfunctional proteins and organelles.
Damage to the endoplasmic reticulum (ER) and Golgi apparatus, leading to deregulated transport of macromolecules and induction of ER stress.
Impaired mitochondrial fission and fusion.
Deregulation of transcription factors.
Disrupted inter-organellar contacts, such as mitochondria-associated ER membranes (MAM).
Parkin is a 52kDa, 465aa E3 ubiquitin-protein ligase with broad-spectrum neuroprotective activities and is found in LB along with α-syn
Anna M. Lenkiewicz,
Acta Neurobiologiae Experimentalis , ISSUE 3, 277–290
: 73 (67–94) days vs. vitamin D3-supplemented group: 101 (74–109) days, p=0.048 Mantel-Cox log rank test). Conclusions: Further investigations are needed to determine whether a neuroprotective or a general corroborative effect of vitamin D leads to the measured effect. Our findings support the potential influence of vitamin D deficiency on the disease course and propose that vitamin D may be an effective supplementary treatment to beneficially influence clinical features
Máté` Fort Molnár,
Acta Neurobiologiae Experimentalis , ISSUE 3, 176–181
Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in
Acta Neurobiologiae Experimentalis , ISSUE 1, 94–105
include: (1) greater glutathione availability in females; (2) greater sulfate-based detoxification capacity in females; (3) potentiating effects of co-exposure to neurotoxicants and testosterone; (4) greater neuroinflammatory response in males; (5) reduced vulnerability to oxidative stress in females; and (6) neuroprotective effects of female hormones (estrogen and progesterone), especially in the reduction of inflammation and oxidative stress.
Janet K. Kern,
David A. Geier,
Kristin G. Homme,
Paul G. King,
Mark R. Geier
Acta Neurobiologiae Experimentalis , ISSUE 4, 269–296
mental and neurological disorders, such as epilepsy, bipolar disorder, depression, schizophrenia, and migraine (Chateauvieux et al., 2010). VPA, a short-chain fatty acid, has attracted considerable interest, due to its neurogenic and neuroprotective effects during SCI treatment, through the inhibition of histone deacetylase (HDAC) and glycogen synthase kinase-3 (GSK-3). Many studies have emphasized the potential role of VPA as an HDAC inhibitor that can upregulate several neurotrophic factors (Jung
Acta Neurobiologiae Experimentalis , ISSUE 1, 38–46