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original-paper | 20-December-2021

Histopathological Analysis of Acinetobacter baumannii Lung Infection in a Mouse Model

be clarified (Eveillard et al. 2010). Animal models for bacterial infection are often considered valuable tools for developing new drugs and vaccines (Byrne et al. 2020). Some mouse models of A. baumannii infection have been established, and immune responses and treatments against the pathogen have been analyzed (Crandon et al. 2009; Qiu et al. 2009a; 2009b; Jacobs et al. 2010). In particular, neutrophils and alveolar macrophages (AMs) play important roles in host resistance to respiratory


Polish Journal of Microbiology, Volume 70 , ISSUE 4, 469–477

Article | 09-November-2020

Frequency of neutrophil-specific antigens among Koreans using the granulocyte indirect immunofluorescence test (GIFT)

NA1, NA2, NB1, NB2, NC1, and NE1 are a group of antigens specifically expressed on neutrophils. Antibodies against neutrophil-specific antigens are involved in alloimmune neonatal neutropenia (ANN), autoimmune neutropenia (AIN), and transfusion-related acute lung injury (TRALI). We investigated the frequencies of NA1, NA2, NB1, and Mart antigens in 105 healthy Korean blood donors (65 males, 40 females) by the granulocyte indirect immunofluorescence test (GIFT) employing flow cytometry. Antigen

Kyou S. Han, Tae H. Um

Immunohematology, Volume 13 , ISSUE 1, 15–16

Report | 06-November-2019

Drug-induced immune neutropenia/ agranulocytosis

Neutrophils are the most abundant white blood cell in blood and play a critical role in preventing infections as part of the innate immune system. Reduction in neutrophils below an absolute count of 500 cells/μL is termed severe neutropenia or agranulocytosis. Drug-induced immune neutropenia (DIIN) occurs when drug-dependent antibodies form against neutrophil membrane glycoproteins and cause neutrophil destruction. Affected patients have fever, chills, and infections; severe infections left

Brian R. Curtis

Immunohematology, Volume 30 , ISSUE 2, 95–101

Review | 14-March-2020

The pathophysiology and prevention of transfusion-related acute lung injury (TRALI):  a review

Transfusion-related acute lung injury (TRALI) is a clinically important complication of transfusion that is often difficult to diagnose, is probably underreported, and likely has a multifactorial origin that is incompletely understood, making it challenging to find effective treatments and preventative steps. The spectrum of its severity and clinical symptoms seems wide, but its pathogenesis is most likely associated with pulmonary damage from activated recipient neutrophils. Despite the

David C. Mair, Ted Eastlund

Immunohematology, Volume 26 , ISSUE 4, 161–173

Article | 20-April-2020

FCGR3B polymorphism in three ethnic Chinese populations

FcγRIIIb receptor is expressed primarily on neutrophils as three polymorphic antigens (HNA-1a, HNA-1b, and HNA-1c) that are encoded by alleles FCGR3B*1, FCGR3B*2, and FCGR3B*3, respectively. These antigens play an important role in immune neutropenia;their absence predisposes individuals who lack them to life-threatening infections. This study investigated the FCGR3B gene frequencies in three ethnic Chinese populations:Han, She, and Tajik. FCGR3B*1, FCGR3B*2, and FCGR3B*3 were genotyped

Lixing Yan, Faming Zhu, Lei Jin, Qinfeng Lv, Qihua Fu

Immunohematology, Volume 21 , ISSUE 1, 25–28

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