research-article | 30-November-2018
tests for a depressive-like state in rodents (Forbes et al., 1996; Castagné et al., 2011).
Moderate concentrations of reactive oxygen species (ROS) are important for a large number of physiological functions (Valko et al., 2007). However, when the concentration of ROS exceeds the antioxidant capacity of the organism, animal cells enter a state called oxidative stress that leads to oxidative damage of cellular components (Aitken et al., 2008). The brain is especially vulnerable to oxidative stress
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 232–238
research-article | 07-July-2020
et al., 2011; Sandin et al., 2012). Additionally, iodine deficiency, even at a sub-clinical level, appear to contribute to an increased risk for both disorders (Blazewicz et al., 2016; Abel et al., 2017). Exposure to environmental pollutants and chemicals has also been suggested to increase the risk of autism and hyperactivity disorder (Dickerson et al., 2015; Tran and Miyake, 2017).
Oxidative stress markers have been found in autism and ADHD, suggesting that increased oxidative stress may
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 129–138
Research paper | 06-February-2018
enzymes, indicating a severe oxidative stress. The elevated brain mitochondrial enzymes like NADH dehydrogenase, and succinate dehydrogenase in the disease control groups, reversed to the near control level after nicorandil treatment. We observed that nicorandil was more effective when given after calcification. It reduced the biochemical alterations associated with calcium and phosphorous toxicity in the brain, by preserving mitochondria, the key target for treating neurodegenerative diseases.
Gino A. Kurian
Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 57–67
research-article | 24-June-2021
neurodegenerative alterations are thought to play a role in the cognitive impairments. It has been suggested that disturbances in receptor levels and neurotransmitter release may lead to apoptosis in neurons which might impair cognitive function in individuals with DM (Moheet et al., 2015; Sadeghi et al., 2016). DM is also defined as a chronic metabolic disorder as it is characterized by increased oxidative stress. It has been reported that oxidative stress contributes greatly to the development of diabetes
Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 2, 1–11
original-paper | 04-June-2020
Oxidative stress refers to an imbalance, which is caused by high levels of reactive oxygen species (ROS) and low levels of antioxidant activity (Preiser 2012). The excessive ROS can damage enzymes, fatty acids, proteins, nucleic acids, and other physiological substances of cells, which leads to structure and function disorders (Dizdaroglu et al. 1992; Wu et al. 2014). The oxidative stress can cause various diseases, including amyotrophic lateral sclerosis, asthma, allergies, and
Polish Journal of Microbiology, Volume 69 , ISSUE 2, 205–215
review-article | 30-November-2020
Characterized by specific neuronal cell losses, neurodegenerative diseases are among the leading cause of disabilities in elderly people (Knight, 1997; Floyd and Hensley 2002, Ricciarelli et al., 2007). Oxidative stress has important roles in the pathogenesis of neurodegenerative diseases. It is known that oxidative stress levels in the brain increase with age (Floyd and Hensley, 2002). Oxidative stress occurs due to the presence of free radicals in high amounts and/or insufficient
Mehmet Arif Icer,
Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 21–33
Human population in the XXI century is struggling with the increasing incidence of such diseases as obesity, diabetes, cancers, food allergies and many others. Recent studies have shown that oxidative stress caused by reactive oxygen species and free radicals, may underlie the occurrence of many diseases. Probiotics are known for their beneficial effects on health and are established as dietary adjuncts. Researchers are trying to find potential probiotic strains which can exhibit antioxidant
Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 1, 18–27
Review | 31-July-2017
Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 269–281
research-article | 15-October-2020
The pathology of Parkinson’s disease (PD) is considered to be multifactorial. In addition to causing alterations in protein transformation, genetic defects and mitochondrial disfunction, the disease also induces chronic neuroinflammation and elevated oxidative stress processes. Neurodegeneration in PD is associated with complex relationships between immune-inflammatory pathways and peripheral tissues. Evidence for peripheral and central chronic inflammation in patients with PD
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 297–304
Research paper | 06-February-2018
observed in some myelinated TCA fibers. In addition, expressions of oxidative markers 3-nitrotyrosine and 4-hydroxynonenal were elevated in barrel field post-lesion. Treatment of antioxidant ascorbic acid or apocynin was able to reverse the increase of oxidative stress and the decline of TCA fiber density, rather than the shrinkage of dendrites and the stripping of dendritic spines of stellate neurons post-lesion. Together, these results indicate that sustained epidural compression of primary
Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 1–17
Review | 04-May-2018
include: (1) greater glutathione availability in females; (2) greater sulfate-based detoxification capacity in females; (3) potentiating effects of co-exposure to neurotoxicants and testosterone; (4) greater neuroinflammatory response in males; (5) reduced vulnerability to oxidative stress in females; and (6) neuroprotective effects of female hormones (estrogen and progesterone), especially in the reduction of inflammation and oxidative stress.
Janet K. Kern,
David A. Geier,
Kristin G. Homme,
Paul G. King,
Mark R. Geier
Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 269–296
Research Article | 21-May-2019
Arsenic is an ubiquitous element present in the environment either through geological or anthropogenic activities. Millions of people all over the world are exposed to arsenic mainly via air, drinking water and food sources, which results in higher incidence of cancer. Several mechanisms by which arsenic compounds induce tumorigenesis have been proposed. Arsenic mediates its toxicity by generating oxidative stress, inducing protein misfolding, promoting genotoxicity, hampering DNA repair and
Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 1, 88–99
original-paper | 04-June-2020
. 2018). Previous studies have shown that MTB lacking MA is less pathogenic in vivo, suggesting that MA plays an important role in MTB’s infection (Slama et al. 2016). Furthermore, MTB promotes bacterial survival by inducing oxidative stress in macrophages (Mohanty et al. 2016). Therefore, the strategy to alleviate the virulence of MTB is to inhibit the biosynthesis of MA, neutralize the oxidative stress produced by MA, and reduce the damage of ROS to intracellular substances.
Polish Journal of Microbiology, Volume 69 , ISSUE 2, 223–229
Article | 30-November-2018
alkaline phosphatase (ALP) activity . The exact mechanism of action of IS in this case is not known, but there are indications that it is related to the production of free radicals and oxidative stress . Another problem in people with CKD is parathyroid hormone (PTH) impairment. The concentration of PTH increases with the decrease of GFR and is an expression of the organism’s defence against the decrease in calcium concentration. Can the change in the composition of a microbiota be one of the
Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 237–245
Review Paper | 04-December-2013
protect the brain against oxidative stress-induced damage suggests a potential use of some flavonoids at least as adjunctive therapy for the treatment of epilepsy.
Journal of Epileptology, Volume 21 , ISSUE 2, 79–87
review-article | 26-March-2021
affect the availability of ACE2 to carry out the mentioned functions. It is also one of the strengths of SARS-CoV-2, when using ACE2 as a binding and entry agent to the host cell it disables the other mechanisms, decreasing the ability of the immune modulating tissue to respond by increasing the oxidative stress, inflammation and apoptosis. This proposed interaction is based on the pathway of the angiotensin II, which it’s binding to the AT1 receptor, leads to cellular damage through the effects
José Luis Cortes-Altamirano,
Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 69–79
research-article | 30-November-2019
; Andreazza et al., 2007). MPH and other neuro-stimulant compounds can cause inflammation, oxidative stress, and mitochondrial dysfunction in brain cells; however the putative mechanism underlying these effects remains unknown (Martins et al., 2006). Interestingly, MPH-induced neurotoxicity seems to be more apparent in certain brain areas, particularly the hippocampus (including CA1, CA2, CA3, and DG subregions) and the amygdala (Morton and Stockton, 2000; Motaghinejad et al., 2017a).
In recent years
Sara Yousefi Moghadam,
Mobina Abbasi Mesrabadi
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 352–366
research-article | 30-November-2020
quadrant (r=0.619, p<0.001).
There was a strong positive correlation between VEGF levels of type 1 and type 2 muscle fibers (r=0.644 p<0.001).
The VEGF levels also negatively correlated with oxidative stress parameters in type 2 fibers (VEGF and SOD levels, r=-0.366, p<0.05; VEGF and GPx levels, r=-0.364, p<0.05).
In addition, there were strong positive correlations among SOD, GPx and MDA levels in type 1 and type 2 fibers (for type 1 muscle fiber: GPx and MDA, r=0.616, p<0.001; for type 2 muscle fiber
Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 1–9
research-article | 30-June-2021
identified in diabetes mellitus that lead to retinopathy and nephropathy (Cade, 2008).
Increasing evidence demonstrates that oxidative stress has a crucial role in the expansion and progression of AD (Sharma and Gupta, 2002). Some studies proposed that amyloid-beta induces lipid peroxide, the creation of hydrogen peroxide, inflammatory cytokines, and superoxide in the brain (Esposito et al., 2006; Huang et al., 1999). Oxidative stress, through the generation of reactive oxygen species (ROS), is the main
Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 2, 141–150
Article | 01-July-2019
consequence, to a reduction in their yielding [38, 110]. In this bacterium, the defence against the oxidative stress caused by the presence of H2O2 is the responsibility of, i.a., KatA and KatB catalases, which break down hydrogen peroxide into water and oxygen. In bacteria, the katA gene is expressed constitutively and the protein encoded by it is the dominant catalase during the logarithmic phase of growth and, in particular, in the stationary phase, and it plays a role in resistance to H2O2 and
Grażyna B. Dąbrowska
Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 2, 127–142