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  • Acta Neurobiologiae Experimentalis

 

Research paper | 14-August-2017

Effectors of large-conductance calcium-activated potassium channel modulate glutamate excitotoxicity
in organotypic hippocampal slice cultures

IbTx-sensitive increase in state 2 respiration of isolated brain mitochondria. In addition,electrophysiological patch-clamp studies confirmed the presence of BKCa channels in mitoplasts isolated from embryonic hippocampal cells. Taken together, our results confirm presence of BKCa channel in rat hippocampal neurons mitochondria and suggest putative role for mitoBKCa in neuroprotection.

Marta Piwońska, Adam Szewczyk, Ulrich H. Schröder, Klaus G. Reymann, Piotr Bednarczyk

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 20–31

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