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case-report | 30-November-2019

Pharmacoresistant epilepsy associated with mutations in the KCNB1 and RELN genes. A case report

(Kwan and Brodie, 2000). It is considered that via biochemical and biological sciences new AED can be developed and perhaps with different mechanisms of action compared to the AED currently on the market. Pharmacoresistant epilepsy is defined as an epilepsy that does not respond to at least two AED, used either in monotherapy or in combination therapy (bi- or polytherapy) and failed to control seizures for a sufficient period of time (Kwan et al., 2010). However, in 2011, the International League

Adamantios Katerelos, Nikolaos Zagkos, Dimitra Alexopoulou, Stella Mouskou, Anastasia Korona, Emmanouil Manolakos

Journal of Epileptology, Volume 28 , 57–61

case-report | 16-February-2019

Ictal asystole with reduced cardiac sympathetic function in new-onset symptomatic epilepsy

and subsequently myoclonic jerks before awakening as an expression of cerebral reperfusion (Duplyakov et al., 2014). MIBG scanning in our patient showed a low post-ganglionic sympathetic innervation in a comparable degree as described in the literature (Druschky et al., 2001; Kerling et al., 2009). In the aforementioned studies, however, patients with ictal asystole and pathological findings on MIBG imaging had been suffering from chronic pharmacoresistant epilepsy either of unknown etiology or

Julia Matzen, Friedhelm C. Schmitt, Michael C. Kreissl, Jürgen Voges, Hans-Jochen Heinze, Imke Galazky

Journal of Epileptology, Volume 27 , 43–47

Original Paper | 22-December-2016

Additive interactions between retigabine and oxcarbazepine in the chimney test and the model of generalized tonic-clonic seizures in mice

Introduction. Patients with pharmacoresistant epilepsy are usually treated with two or more antiepileptic drugs (AEDs). The search for therapeutically efficacious AED combinations is still a challenging issue for clinicians and epileptologists throughout the world. Aim. To determine the interaction profile for the combination of retigabine (RTG) and oxcarbazepine (OXC) in both, the model of tonic-clonic seizures, the maximal electroshock (MES)-induced seizure model and chimney test (motor

Mirosław Zagaja, Barbara Miziak, Katarzyna Załuska, Paweł Marzęda, Bartłomiej Drop, Karolina Załuska-Patel, Grażyna Ossowska, Stanisław J. Czuczwar, Jarogniew J. Łuszczki

Journal of Epileptology, Volume 24 , ISSUE 2, 87–94

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