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  • Acta Neurobiologiae Experimentalis



Modulation of catalase, copper and zinc in the hippocampus and the prefrontal cortex in social isolation-induced depression in male rats

depression in socially isolated people is not fully understood. In this study, we hypothesized that fourteen days of social isolation would lead to a reduction in zinc and copper levels and catalase activity in the hippocampus and prefrontal cortex that may contribute to the occurrence of depression. The prefrontal cortex is a brain region often investigated in psychiatric illnesses (Vostrikov et al., 2007). The hippocampus is also of particular importance for studying depressive and anxiety behavior

Hamidreza Famitafreshi, Morteza Karimian

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 184–192


Measurement of Brain Activity Related to Unpleasant Emotion in the Prefrontal Cortex Region Using NIRS

We measured noninvasively a response of blood flow (hemoglobin concentration) in the prefrontal cortex area caused by emotional unpleasant arousal using the near-infrared spectroscopy (NIRS). NIRS can be easily measured brain activity in comparison with other measurement methods. And it has the advantage of low load for subjects. In this study, auditory stimuli applied to subjects in order to arouse unpleasant emotions, changes in blood flow were measured at that time. As a result, we have

Haruki Kawanaka, Atsushi Nagase, Koji Oguri

International Journal of Advanced Network, Monitoring and Controls, Volume 1 , ISSUE 1, –

Short Communication

Somatic and dendritic perforated-patch recordings reveal β-adrenergic receptor-induced depolarization in medial prefrontal cortex pyramidal neurons

The aim of this perforated-patch study was to test the effect of isoproterenol on the membrane potential in mPFC (medial prefrontal cortex) pyramidal neurons. Isoproterenol depolarized the membrane potential recorded from the soma. This effect was absent in the presence of metoprolol, suggesting the involvement of β1-adrenergic receptors. The adenylate cyclase activator forskolin also depolarized the membrane potential. Moreover, the effect of isoproterenol was abolished by the adenylate

Bartłomiej Szulczyk

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 2, 158–164

Research paper

Effects of repetitive transcranial magnetic stimulation on non-veridical decision making

We test the emerging hypothesis that prefrontal cortical mechanisms involved in non-veridical decision making do not overlap with those of veridical decision making. Healthy female subjects performed an experimental task assessing free choice, agent-centered decision making (The Cognitive Bias Task) and a veridical control task related to visuospatial working memory (the Moving Spot Task). Transcranial magnetic stimulation (TMS) was applied to the left and right dorsolateral prefrontal cortex

Jaan Tulviste, Elkhonon Goldberg, Kenneth Podell, Talis Bachmann

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 182–191


Effects of HTR1A rs6295 polymorphism on emotional attentional blink

the advancement of societal health-care policies by genotyping based screening practices. Activity in the dorso-lateral prefrontal cortex (DLPFC) has been shown to be involved in the control of attention when responding to threatening stimuli in the context of emotional attentional blink (EAB) assessment (Peers et al., 2013). It is also known that depression is characterized by hypoactivity of the DLPFC (Groenewold et al., 2013) and targeting DLPFC with non-invasive neuromodulation such as

Kadi Tulver, Madis Bachmann, Mariliis Vaht, Jaanus Harro, Talis Bachmann

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 389–399

Research paper

The influence of mood on visual perception of neutral material

observed higher activation of visual areas after positive mood induction and lower activations in medial prefrontal and right frontotemporal regions after negative mood induction. We conclude that in relatively safe laboratory conditions, after being exposed to negative emotional content, automatic processes of affective control are recruited by the prefrontal cortex. This results in attenuation of processing of incoming stimuli, as the stimuli do not carry salient information with respect to bottom-up

Miroslaw Wyczesany, Tomasz S. Ligeza, Agnieszka Tymorek, Agnieszka Adamczyk

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 2, 163–172

Research paper

The effects of edaravone in ketamine-induced model of mania in rats

order to evaluate oxidative damage in the rat hippocampus and prefrontal cortex. Increased locomotor activity (hyperlocomotion) was observed at the open-field test with ketamine treatment (25 mg/kg, i.p., 8 days). Edaravone (18 mg/kg) treatment did not prevent hyperlocomotion in the mania model induced with ketamine in rats, but lithium chloride (47.5 mg/kg, i.p., positive control) did prevent hyperlocomotion. Edaravone and lithium chloride treatments were found to reduce the increase in SOD and CAT

Filiz Civil Arslan, Ahmet Tiryaki, Mehmet Yıldırım, Evrim Özkorumak, Ahmet Alver, İlkay Keleş Altun, İmran İnce, Öznur Gedikli

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 192–198

Research paper

BDNF gene polymorphisms and haplotypes in relation to cognitive performance in Polish healthy subjects

Making Test (TMT), the Stroop Test which are to a large extent connected with prefrontal cortex activity. Our sample consisted of 460 healthy participants from Polish population. We detected possible association between five BDNF polymorphisms (rs11030101, rs10835210, rs2049046, rs2030324, rs2883187) and TMT_A. Additionally, one haplotype block made from eleven BDNF variants (rs2883187, rs1401635, rs2049046, rs2030324, rs11030101, rs10835210, rs1013402, rs1401635, rs1013402), as

Monika Wiłkość, Agnieszka Szałkowska, Maria Skibińska, Ludmiła Zając-Lamparska, Małgorzata Maciukiewicz, Aleksander Araszkiewicz

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 43–52

Research paper

The relationship between alpha burst activity and the default mode network

cortex/precuneus (PCC) source channel was less related to the OCC than to the DMN source channels. The fMRI analysis performed using the PCC-ABS as a general linear model regressor indicated an increased blood oxygenation level-dependent signal change in DMN nodes – precuneus and prefrontal cortex. These results confirm the OCC source of alpha activity and additional specific sources of ABS in the DMN.

Mateusz Rusiniak, Andrzej Wróbel, Katarzyna Cieśla, Agnieszka Pluta, Monika Lewandowska, Joanna Wójcik, Piotr H. Skarżyński, Tomasz Wolak

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 2, 92–106


On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients – a DTI study

studies showed that enhancement of the oxytocin transmission can affect functional connectivity between precuneus - amygdala (Kumar et al., 2015) or precuneus - left dorsolateral prefrontal cortex (Kumar et al., 2019) connections. The above findings support the theory on the contribution of the precuneus to the social cognition in schizophrenia, mediated by oxytocin level decrease, which is strongly related to one related deficit of social cognition - the severity of asociality (Guessoum et al., 2020

Przemysław Adamczyk, Olga Płonka, Dawid Kruk, Martin Jáni, Piotr Błądziński, Aneta Kalisz, Stynke Castelein, Andrzej Cechnicki, Miroslaw Wyczesany

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 80–95


Stimulus-seeking in rats is accompanied by increased c-Fos expression in hippocampal CA1 as well as short 22 kHz and flat 50 kHz calls

prefrontal cortex (PFC) which includes PrL and IL and exerts control of sensory and affective behaviours by active projections to other cortical and subcortical regions. Some PFC projections target the nucleus accumbens, a central node of reward circuitry, which is known for translating motivation into action (Klawonn and Malenka, 2019) and plays a role in several brain functions, including pain responses (Zhou et al., 2018), reward (Balleine 2005, Klawonn and Malenka, 2019), instrumental learning (Britt

Ita Robakiewicz, Monika Polak, Małgorzata Rawska, Dominik Alberski, Rafał Polowy, Kinga Wytrychiewicz, Mateusz Syperek, Jan Matysiak, Robert K. Filipkowski

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 310–318

Research paper

Potential role of dopamine transporter in behavioral flexibility

Behavioral flexibility is subserved by the prefrontal cortex and the basal ganglia. Orbitofrontal cortex (OFC) and dorsomedial striatum (DMS) form a functional frontocorticostriatal circuit crucial for the mediation of flexibility during reversal learning via dopamine (DA) neurotransmission. The regulatory control in maintaining DA homeostasis and function is provided by the dopamine transporter (DAT), which therefore likely plays a significant role in controlling the influence of DA on

Anita Cybulska-Klosowicz, Julia Dabrowska, Sebastian Niedzielec, Renata Zakrzewska, Aleksandra Rozycka

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 2, 176–189


Alteration of oxidative stress markers and behavior of rats in a novel model of depression

, using a digital camera and RealTimer software (Open Science, Russia). Previous studies have validated the applied protocol with antidepressant treatment (Morozova et al., 2016). Sacrifice and brain dissection All rats from each group were euthanized with ketamine injection of 0.01 ml/g body weight and sacrificed by cervical dislocation. For fluorometric assays the brain of each rat was dissected, and the hippocampi and prefrontal cortex were isolated as described elsewhere (Chiu et al., 2007

Anna Gorlova, Dmitrii Pavlov, Eugene Zubkov, Yana Zorkina, Anatoly Inozemtsev, Anna Morozova, Vladimir Chekhonin

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 232–238

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