channel in epileptogenesis has not yet been evaluated. Considering the physiological and pharmacological features of the TRPM8 channel, we aimed to evaluate the effect of a selective TRPM8 antagonist in different experimental models of seizure.
Eight-day-old male Wistar rat pups (13–15 g) were used for induction of febrile seizures. Male albino mice (25–30 g) were used for PTZ- and electroshock-induced convulsions. The animals were housed under standard conditions (22–25°C and 12 h light
Nosaibeh Riahi Zaniani,
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 86–91
Rat model data remains inconclusive regarding methadone effects on myelination. Rat pups with antenatal exposure to methadone via an osmotic minipump implanted in the pregnant dam demonstrated an up-regulation of myelin production and altered structure (Vestal-Laborde et al., 2014). Alternatively, rat pups with antenatal exposure to methadone via drinking water demonstrated decreased expression of myelin-specific proteins (Gourevitch et al., 2016).
Detoxification during pregnancy has been
Lori A. Devlin,
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 367–373