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  • Acta Neurobiologiae Experimentalis

 

research-paper

Protective effects of M8-B, a TRPM8 antagonist, on febrile- and pentylenetetrazol-induced seizures

channel in epileptogenesis has not yet been evaluated. Considering the physiological and pharmacological features of the TRPM8 channel, we aimed to evaluate the effect of a selective TRPM8 antagonist in different experimental models of seizure. METHODS Eight-day-old male Wistar rat pups (13–15 g) were used for induction of febrile seizures. Male albino mice (25–30 g) were used for PTZ- and electroshock-induced convulsions. The animals were housed under standard conditions (22–25°C and 12 h light

Nazanin Zandi, Nosaibeh Riahi Zaniani, Ali Moghimi, Ali Roohbakhsh

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 86–91

research-article

Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure

). Rat model data remains inconclusive regarding methadone effects on myelination. Rat pups with antenatal exposure to methadone via an osmotic minipump implanted in the pregnant dam demonstrated an up-regulation of myelin production and altered structure (Vestal-Laborde et al., 2014). Alternatively, rat pups with antenatal exposure to methadone via drinking water demonstrated decreased expression of myelin-specific proteins (Gourevitch et al., 2016). Detoxification during pregnancy has been

Rahul Oberoi, Tianci Chu, Nicholas Mellen, Rekha Jagadapillai, Hezhong Ouyang, Lori A. Devlin, Jun Cai

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 367–373

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