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Research paper | 04-May-2018

Interaction between the serotoninergic and GABAergic systems in frog retina as revealed by electroretinogram

Functional interactions between serotoninergic and GABAergic systems in the vertebrate retina are largely unknown. In this study, the effects of isolated or combined stimulation of the serotonin receptors (with 100 µM serotonin) and ionotropic GABAA and GABAC receptors (with 5 mM TACA) on the electroretinographic (ERG) ON (b-wave) and OFF (d-wave) responses were investigated in frog eyecup preparations. It was found that serotonin alone produced a significant enhancement of the band d-wave

Elka Popova, Petia Kupenova

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 351–361

research-article | 07-July-2020

Effects of HCN channel blockade on the intensity-response function of electroretinographic ON and OFF responses in dark adapted frogs

INTRODUCTION Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are cation channels that open when the membrane potential is hyperpolarized. The HCN family consists of four isoforms (HCN1–4), which possess different kinetics, voltage-dependence and modulation by cyclic nucleotides (for review: Sartiani et al., 2017). Expression of all isoforms has been demonstrated in the vertebrate retina: tiger salamander (Barrow and Wu, 2009), rat (Müller et al., 2003; Ivanova and Müller

Elka Popova, Petia Kupenova

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 192–204

research-article | 24-June-2019

The influence of fixation stability on balance in central vision loss

(Tarita-Nistor et al., 2011). Some visual impairments cause disease in this region of the eye. In order to compensate for the loss of a functioning fovea, those affected recruit their remaining functional peripheral retina to accomplish daily tasks, with varying degrees of success. This results in the formation of eccentric, sometimes stable, but often unstable, non-central fixation points or preferred retinal loci (PRLs) (Schuchard, 2005; Seiple et al., 2005). Individuals with central vision loss

Caitlin Murphy, Michael Kapusta, Olga Overbury

International Journal of Orientation & Mobility, Volume 10 , ISSUE 1, 1–9

Research paper | 15-January-2019

Dopamine D2 receptor blockade differentially affects the light-adapted turtle and frog electroretinogram

differences between dopamine D2-class receptor-mediated pathways in turtle and frog retina (revealed by ERG).

Elka Popova, Petia Kupenova

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 332–342

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