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  • Acta Neurobiologiae Experimentalis


Research paper

Interaction between the serotoninergic and GABAergic systems in frog retina as revealed by electroretinogram

Functional interactions between serotoninergic and GABAergic systems in the vertebrate retina are largely unknown. In this study, the effects of isolated or combined stimulation of the serotonin receptors (with 100 µM serotonin) and ionotropic GABAA and GABAC receptors (with 5 mM TACA) on the electroretinographic (ERG) ON (b-wave) and OFF (d-wave) responses were investigated in frog eyecup preparations. It was found that serotonin alone produced a significant enhancement of the band d-wave

Elka Popova, Petia Kupenova

Acta Neurobiologiae Experimentalis , ISSUE 4, 351–361

Research paper

Marble burying as compulsive behaviors in male and female mice

receptor or a “pure” inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD. A burying paradigm that more precisely mimics the human condition was used, e.g., testing in the home environment, chronic drug exposure and acknowledging individual differences by pre-selecting for high marble burying. Results were that there were no sex differences in groups treated with drugs or in control mice. Both diazepam and escitalopram decreased numbers of

George T. Taylor, Sandra Lerch, Sabine Chourbaji

Acta Neurobiologiae Experimentalis , ISSUE 3, 254–260

Research paper

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug development. However, predictive validity of this model is poorly documented. There is a close interaction between itch and pain sensations with regard to mediation through an anatomically and functionally identical neuronal pathway. One approach is whether the existing

Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin

Acta Neurobiologiae Experimentalis , ISSUE 3, 234–243


The effect of bupropion augmentation of minocycline in the treatment of depression

multiple receptor-acting drugs like bupropion, mirtazapine, trazodone and nefazodone may be positively influenced by decreased adverse reactions due to decreased affinities for other systems (Bondy, 2002). Studies have demonstrated that bupropion increases monoaminergic neurotransmission in a different manner compared to several other antidepressants. In rat and mouse studies, presynaptic (by affecting serotonin release or reuptake) and postsynaptic (by binding to serotonin receptors) alteration of

Monica Bendale, Sharon Ronald D'souza, Veeranjaneyulu Addepalli, Pravin Popatrao Kale

Acta Neurobiologiae Experimentalis , ISSUE 2, 217–224


Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

. Cadmium exposure has also been shown to alter the activity of acetylcholinesterase and sodium-potassium ATPase in various rat brain regions including cortex, hippocampus, cerebellum, striatum and hypothalamus (Wang et al., 2018). Abdel Moneim et al. (2014) observed reduced levels of dopamine and serotonin and increased lipid peroxidation in rats following intraperitoneal administration of cadmium for five days. These authors also reported an increased generation of reactive nitrogen species and

Zehra Batool, Faiza Agha, Saiqa Tabassum, Tuba Sharf1 Batool, Rafat Ali Siddiqui, Saida Haider

Acta Neurobiologiae Experimentalis , ISSUE 2, 169–183

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