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  • Acta Neurobiologiae Experimentalis

 

Research paper

Effects of individual stressors used in a battery of “chronic unpredictable stress” on long-term plasticity in the hippocampus of juvenile rats

We have studied alterations in the properties of long-term potentiation (LTP) in hippocampal slices of juvenile rats induced by the exposure of animals to different individual stressors usually used in batteries of chronic unpredictable stress (CUS), a widely used model of depression. Social isolation for 16 h did substantially affect neither the magnitude and nor the development of LTP. The effects of stroboscopic illumination and water deprivation appeared most severe, though opposite: the

Alexandra A. Gorbunova, Irina V. Kudryashova, Anna O. Manolova, Margarita R. Novikova, Mikhail Yu. Stepanichev, Natalia V. Gulyaeva

Acta Neurobiologiae Experimentalis , ISSUE 3, 244–253

research-paper

Modulation of catalase, copper and zinc in the hippocampus and the prefrontal cortex in social isolation-induced depression in male rats

, exploring factors that regulate this complex disease can be of great importance in controlling the illness. Environmental and genetic factors contribute to the occurrence and relapse of psychiatric diseases (Meyer-Lindenberg and Weinberger, 2006). Although both factors are important, the precise roles of environment and genetics have yet to be determined. In this study, we hypothesized that social isolation can favor mechanisms leading to the occurrence of depressive-like behavior. Social isolation has

Hamidreza Famitafreshi, Morteza Karimian

Acta Neurobiologiae Experimentalis , ISSUE 2, 184–192

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