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  • Acta Neurobiologiae Experimentalis


research-article | 07-July-2020

Hypothermia in the course of acute traumatic spinal cord injury

INTRODUCTION Traumatic spinal cord injury (SCI) is a life-threatening neurological condition resulting in partial or complete loss of motor, sensory and autonomic innervation below the injury level. The consequences of SCI include not only a decreased quality of life for the injured but also an adverse socio-economic impact on their relatives and society as whole (Piatt et al., 2016; Nori et al., 2017). Despite recent progress in the understanding of SCI pathophysiology and progress in

Jozef Kafka, Nadezda Lukacova, Igor Sulla, Marcela Maloveska, Zuzana Vikartovska, Dasa Cizkova

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 172–178

Research paper | 15-January-2019

Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats

Spinal cord injury leads to a robust inflammatory response that is an unfavorable environment for stem cell implantation. In this study, we evaluated the effect of combined therapy of curcumin and mesenchymal stem cells (MSC) on behavioral recovery and tissue sparing, glial scar formation, axonal sprouting and inflammatory responses in a rat experimental model of spinal cord injury (SCI). Balloon-induced compression lesion was performed at thoracic (Th8-9) spinal level. Out of the four groups

Jiri Ruzicka, Lucia Machova Urdzikova, Anna Kloudova, Anubhav G. Amin, Jana Vallova, Sarka Kubinova, Meic H. Schmidt, Meena Jhanwar-Uniyal, Pavla Jendelova

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 358–374

review-article | 30-November-2019

Spinal cord regeneration using dental stem cell-based therapies

INTRODUCTION Spinal cord injury (SCI) is a devastating neurological disorder resulting in the permanent sensory and motor dysfunctions due to loss of glia, neurons and the incomplete axonal regeneration after injury (Silva et al., 2014; Ahuja et al., 2017). SCI varies in incidence around the world, depending on the land transport, type of infrastructure, culture and socioeconomic levels between countries (Lee et al., 2014). The complicated pathophysiology of SCI has been extensively studied in

Yifan Xu, Meikai Chen, Tan Zhang, Yuliang Ma, Xuerong Chen, Ping Zhou, Xiaofeng Zhao, Fei Pang, Wenqing Liang

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 319–327

Research paper | 15-January-2019

Neurological improvement in patients with chronic spinal cord injury treated with leuprolide acetate, an agonist of GnRH

It has been reported that gonadotropin-releasing hormone (GnRH), and its analogue leuprolide acetate (LA), have neurotrophic properties; particularly in the regeneration of injured spinal cord in animal models and in the case of a patient with spinal cord injury (SCI). The aim of this study was to establish whether treatment with LA improves sensitivity, motor activity and independence in patients with chronic SCI. Patients were treated LA once a month for six months. They were evaluated at the

José Luis Quintanar, Carmen Díaz-Galindo, Denisse Calderón-Vallejo, Irma Hernández-Jasso, Froylán Rojas, Daniel Medina-Aguiñaga, Carlos Olvera-Sandoval

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 352–357

Research paper | 04-May-2018

Axonal outgrowth stimulation after alginate/mesenchymal stem cell therapy in injured rat spinal cord

Juraj Blaško, Eva Szekiova, Lucia Slovinska, Jozef Kafka, Dasa Cizkova

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 337–350

research-article | 06-April-2020

Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

INTRODUCTION Brain-derived neurotrophic factor (BDNF) and glial-cell-derived neurotrophic factor (GDNF) are both related to the neurotrophic factor family, which play essential roles in neural development, cell survival, differentiation, and axonal growth, in both the central and peripheral nervous systems, during development and in mature systems (Marsh and Blurton-Jones, 2017). During neurodegenerative disorders, such as spinal cord injury (SCI), Alzheimer’s disease, and Huntington’s disease

Zahra Baharvand, Mohammad Nabiuni, Mohammad Tahmaseb, Elaheh Amini, Sareh Pandamooz

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 38–46

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