The first confirmed transfer of genetic material in human was performed in 1990. Ever since, gene therapy was considered to be one of the best promising treatments of genetic diseases. The sine qua non of successful gene therapy are efficient genetic vectors. Recently, the most frequently used vectors in clinical trials for genetic therapies are virus-based and plasmid-based. A range of features makes plasmids useful for gene therapy, however, they have also some characteristics which make it
Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 2, 214–225
West syndrome (WS) is one of the most common epileptic encephalopathies. While it affects predominantly infants with various cerebral disorders, it may also present itself in initially healthy children. The absence of adequate therapy which allows to arrest infantile spasms (IS) and hypsarrhythmia in most cases leads to an regression of psychomotor development and severe disabilities. Development of effective treatment protocols for WS is therefore an urgent matter of scientific and
Iosif V. Volkov,
Oksana K. Volkova,
Olga S. Tashkinova,
Elena D. Belousova
Journal of Epileptology, Volume 26 , ISSUE 1-2, 55–61
Background:Little research has been undertaken on children and adolescents with psychiatric co-morbidity and this group is seldom subject to evidence-based treatment. Equally, there has been little research on creating an evidence base for Narrative Therapy, which means that narrative family therapy (NFT) is seldom available to children and adolescents with a psychiatric disorder.Objective:A single group clinical design was used to examine the efficacy of NFT for children and adolescents with
Nina Tejs Jørring,
Karsten Gjessing Jensen
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 6 , ISSUE 2, 107–114
Unreasonable antibacterial therapy is suspected to be the main reason of emergence of multi-resistant bacteria. The connection between seasonal variability of antibiotic use and reasonable antibacterial therapy has been described. We examined the issue basing on the data obtained from the primary care system in Szczecin (Poland) in order to verify the situation in this region of Central Europe. Increase in antibiotic consumption in a viral infection season was proved to be statistically
Eligia M. Szewczyk
Polish Journal of Microbiology, Volume 66 , ISSUE 1, 119–123
To improve the human arm function of disable patients after stroke, we propose in this paper a new design of a robot-assisted therapy. The robotic device must be attached to a human arm and mimics the motion of the shoulder, elbow and wrist joints. The functional training of the stroked upper limb is covered in motion and force via a safe compliant motion. The controller parameters are optimized by the therapist based on the human morphology parameters via an intelligent Control Interface where
International Journal on Smart Sensing and Intelligent Systems, Volume 5 , ISSUE 4, 1044–1062
. Compassion-focused therapy (CFT) was originally developed to help people experiencing chronic and complex MH problems and those experiencing high levels of shame and self-criticism to cultivate a compassionate care orientation toward themselves and others (18, 19). CFT is an integrative multi-modal therapy based on evolutionary psychology, attachment theory, neuroscience, and cognitive behavior theory. An essential aspect of CFT is compassionate mind training to help individuals to experience warm
Anna Sofia Bratt,
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 8 , 38–47
individuals sharing a socially and emotionally supportive interaction (11). Peer support has proven effective in both non-veteran populations (12-14) and veteran populations (1, 15-19). However, there are few veteran peer support studies that examine the long-term effectiveness of such interventions.
Outdoor therapy is another approach to mental health care. Outdoor therapy involves exposure to natural outdoor environments (20) for therapeutic purposes. Outdoor therapy has proven effective in non-veteran
Eat, Sleep, Work, Volume 3 , 39–53
). In the Treatment of Selective Serotonin Reuptake Inhibitor-Resistant Depression in Adolescents Study, adolescent report of more parent-adolescent conflict was also found to be a non-specific predictor of nonresponse (11). Mother-report of frequent and intense conflict was similarly found to be a non-specific predictor of poor outcomes in an exploratory analysis of data from the Treatment of Adolescent Depression Study (12).
However, in a trial comparing Interpersonal Therapy to treatment as usual
Erling W. Rognli,
Nikolai O. Czajkowski,
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 8 , 110–122
The gold standard in microbiological diagnostics of bacteremia is a blood culture in automated systems. This method may take several days and has low sensitivity. New screening methods that could quickly reveal the presence of bacteria would be extremely useful. The objective of this study was to estimate the effectiveness of these methods with respect to blood cultures in the context of antibiotic therapy. Blood samples from 92 children with sepsis were analyzed. Blood cultures were
TOMASZ W. ŹRÓDŁOWSKI,
Polish Journal of Microbiology, Volume 67 , ISSUE 4, 479–486
treatment in clinical practice, as a dissemination problem. They highlight a need for spreading knowledge of effective treatments aimed at youths with anxiety disorders and training therapists in these treatments, thus making treatment more available and the therapists conducting the treatment more qualified (12).
The efficacy of cognitive behavioral therapy (CBT) treating anxiety disorders among youths have been thoroughly tested in several randomized controlled trials (RCT). A systematic review of 41
Daniel Bach Johnsen,
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 7 , 68–80
. Ultrasound also allows to monitor the outcome of methotrexate therapy. This study is a review of literature regarding the management of ectopic pregnancy with methotrexate. Such ultrasound findings as the size of the ectopic mass, presence of fetal heart rate and free fluid have been confirmed as effective eligibility criteria for therapy with methotrexate. In the future, possibly also endometrial stripe thickness and the vascularity of the ectopic mass may be considered predictive of successful
Journal of Ultrasonography, Volume 18 , ISSUE 73, 158–161
conducted through an independent narrative literature review on PubMed and Medline databases. We selected articles in Portuguese, English, French and Spanish, with no restriction to the date of publication. The search was performed using combinations of the following terms: epilepsy treatment, rational therapy/polytherapy, supraadditive treatment, drug-resistant epilepsy treatment. Cited references within selected articles were also evaluated.
Rational polytherapy. Myth?
José Manuel Lopes Lima
Journal of Epileptology, Volume 27 , 27–34
Background. The lifetime risk of patients with brain tumors to have focal epileptic seizures is 10–100%; the risk depends on different histology. Specific guidelines for drug treatment of brain tumor-related seizures have not yet been established. Aim. This review addresses the special aspects of antiepileptic drug (AED) therapy in brain tumor-related epilepsy. Methods. We analyzed the literature up to December 2015. Results. Based on current evidence the management of tumor-related
Journal of Epileptology, Volume 24 , ISSUE 1, 41–56
measured at 12–24 h (Wei W et al. 2009; Fu Y et al. 2014). The inflammatory cells including macrophages regulate inflammatory responses by the induction of significant inflammation and release of inflammatory cytokines (IL-1β, IL-6, and TNF-α) and chemokines (Kim et al. 2015) at the high concentrations.
Our study is the first to explore the combination of TZ, MCZ, and CXN in the treatment of mastitis using a mouse model to provide a basis for subsequent combined antibacterial therapy.
Polish Journal of Microbiology, Volume 68 , ISSUE 4, 477–491
–46 mg/l (Jacob and Nair, 2016). Since both drugs are eliminated via the kidneys, the dosage has to be adapted to renal function especially in renal replacement therapy (RRT). A comprehensive evaluation of literature concerning the effect of RRT on the pharmacokinetics of AEDs performed in May 25th 2016 (Smetana et al., 2016) identified just one paper on the use of LCM during intermittent haemodialysis (IHD) (Cawello et al., 2013) and two case reports on the use of LEV with continuous venovenous
Journal of Epileptology, Volume 28 , 33–36
transfusions. A 66-year-old Caucasian female with coronary artery disease and a history of refractory AIHA had recently developed anemia and required multiple RBC transfusions. The patient had maintained adequate RBC counts with erythropoietin and prednisone therapy for the previous 16 months. With the recent worsening of her hemolytic anemia,she had developed angina that was treated with RBC transfusions in an outpatient setting. However, her angina increased as her RBC counts decreased, leading to
Annika M. Svensson,
Mark K. Fung
Immunohematology, Volume 20 , ISSUE 3, 177–183
Microbial colonisation of chronic venous ulcers and synergism between bacterial species slow down the healing process. The study aimed at performing qualitative analysis of microbial flora in venous leg ulcers treated with platelet rich plasma (PRP). Twenty two women and twelve men aged 47–90 years were treated with PRP at our department between 2012 and 2015. Ulcer cultures collected before and after PRP therapy yielded 83 and 110 microbial isolates, respectively, of Gram positive, Gram
R. Krzysztof Mlosek,
Polish Journal of Microbiology, Volume 65 , ISSUE 3, 353–357
The paper suggests a method for determining the optimal location of service points (warehouses) based on the method for optimal planning of radiation therapy of malignant tumors. This method enabled us to identify the location of the most optimal number of warehouses taking into account their capacity for the required volume of freight transportation and distance from warehouses to consumers. The results of the study coincide with the results obtained by using the method of ant algorithm. The
Transport Problems, Volume 13 , ISSUE 4, 144–155
Spinal cord injury leads to a robust inflammatory response that is an unfavorable environment for stem cell implantation. In this study, we evaluated the effect of combined therapy of curcumin and mesenchymal stem cells (MSC) on behavioral recovery and tissue sparing, glial scar formation, axonal sprouting and inflammatory responses in a rat experimental model of spinal cord injury (SCI). Balloon-induced compression lesion was performed at thoracic (Th8-9) spinal level. Out of the four groups
Lucia Machova Urdzikova,
Anubhav G. Amin,
Meic H. Schmidt,
Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 358–374
antibodies (GAPAs) in our institution. Adult patients who received gentamicin from 1/1/98 to 7/31/98 were evaluated for inclusion in the study. Testing for the presence of GAPAs was performed if the patient had a decrease in platelet count while receiving gentamicin or if the platelet count increased or decreased within 3 days of the last gentamicin therapy. Patients receiving gentamicin without development of thrombocytopenia were tested as controls. During the study period, 926 patients
Miriam Fogg Leach,
James P. AuBuchon
Immunohematology, Volume 15 , ISSUE 4, 167–170
). Community- or healthcare-acquired UTIs are clinically divided into complicated or uncomplicated, and among many other factors, this classification determines what antimicrobial agents can be applied for treatment (Zacchè and Giarenis 2016). Complicated UTIs require prolonged therapy and occur in patients with renal failure, anatomical urinary tract abnormalities such as urinary obstruction and retention or in patients that use medical devices such as a catheter. Complicated UTIs are also associated with
Polish Journal of Microbiology, Volume 68 , ISSUE 4, 403–415
This study compared the outcome of photosensitization on the viability of four different cariogens in planktonic form as well as biofilms in human dentine. Photodynamic therapy was carried out with a gallium aluminium arsenide laser (670 nm wavelength) using Toluidine blue O (TBO) as the photosensitizer. Cariogenic bacteria (Streptococcus mutans, Lactobacillus casei, Streptococcus salivarius and Actinomyces viscosus) were exposed to TBO and then to the laser for 1 minute in planktonic
KHITAM H. TAWALBEH,
AHMAD S. AL-HIYASAT,
Polish Journal of Microbiology, Volume 67 , ISSUE 4, 455–462
;), 3.04 percent C−, 2.39 percent e−, and 5.17 percent M−. The high prevalence of C, e, and Fya and immunogenicity of these antigens may induce alloimmunization in transfusion-dependent patients, creating difficulties providing blood from Lao donors. The information obtained from this study will be useful for improving transfusion therapy in the country, especially for estimation of the availability of compatible blood for patients who have produced antibodies.
Immunohematology, Volume 28 , ISSUE 4, 132–136
Despite strong efforts in the field, spinal cord trauma still belongs among the untreatable neurological conditions at present. Given the complexity of the nervous system, an effective therapy leading to complete recovery has still not been found. One of the potential tools for supporting tissue regeneration may be found in mesenchymal stem cells, which possess anti-inflammatory and trophic factor-producing properties. In the context of transplantations, application of degradable biomaterials
Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 337–350
One-session treatment (OST) is a short-term massed exposure therapy for the treatment of specific phobias in children and adults. Systematic reviews have demonstrated the effectiveness of the treatment for children and adolescents across countries and age groups.A single-group open trial design was used to examine the feasibility and preliminary efficacy of OST for youths with specific phobias in a Danish context.At the Anxiety Clinic of Aarhus University, 10 youths between the ages of 7 and 17
Mette Djernes Nielsen,
Christina Linddahl Andreasen,
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 4 , ISSUE 2, 65–76
Immunohematology, Volume 23 , ISSUE 1, 20–33
Corina E. Gonzalez
Immunohematology, Volume 20 , ISSUE 1, 71–71
Journal of Epileptology, Volume 22 , ISSUE 2, 109–112
Positive direct antiglobulin tests (DATs) associated with cephalosporin therapy have been reported, but rarely were associated with immune hemolytic anemia (IHA). In 1989, we described the first case of IHA associated with cefotetan (Cefotan™) causing hemolysis by the drug-adsorption mechanism. We now report the full details of our investigation. The patient was a 23-year-old female with a 2 1/2 year history of chronic ulcerative colitis. After 4 days of therapy with cefotetan (2 g/day
Robert J. Eckrich,
Immunohematology, Volume 10 , ISSUE 2, 51–54
The clinical course of warm autoimmune hemolytic anemia (WAIHA) can be perplexing and frustrating. Although many patients respond to standard therapy in a predictable and timely fashion, some patients are refractory to standard therapy and may require several attempts of therapies that are less well established. The focus of this review is to discuss the various pharmacologic approaches and options for the treatment of WAIHA.
Karen E. King
Immunohematology, Volume 23 , ISSUE 3, 120–129
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a relatively new autoimmune disorder of the central nervous system. We report the first case of anti-NMDAR autoimmune encephalitis combined with anti-voltage-gated potassium channel (anti-VGKC) antibodies in Lithuania in a 16-year-old girl. The patient was admitted to psychiatry unit because of an acute psychotic episode. She was unsuccessfully treated with antipsychotics, and electroconvulsive therapy was initiated because of her
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 5 , ISSUE 3, 111–115
Immunohematology, Volume 19 , ISSUE 3, 94–94
(Vishnubhatla et al., 2014). Despite the remarkable results reported so far from the early phase trials of stem cell therapy (Matsa et al., 2014), it should be noted that the therapeutic benefits cannot be necessarily attributed to stem cells (Hicks et al., 2013). Indeed, recent studies show that the efficiency of cell implants cannot be achieved without long-term cell survival and cell-conditioned culture medium, suggesting an essential role of secreted paracrine factors (Bi et al., 2007). The paracrine
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 262–270
estimated that annually in the United States, at least 2 million patients are diagnosed with infectious diseases caused by bacteria resistant to one or more groups of antibiotics. Moreover, nearly 23,000 of these patients die and the immediate cause of death is the developing infection due to ineffective antimicrobial therapy . Data from the CDC report indicates that in the USA more than 14,000 patients are diagnosed with the so-called Healthcare Associated Infections (HAI) caused by Enterobacterales
Sylwia Joanna Chmielewska,
Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 271–289
John D. Roback
Immunohematology, Volume 19 , ISSUE 2, 62–62
International Journal on Smart Sensing and Intelligent Systems, Volume 6 , ISSUE 1, 1–17
lesions in the lower extremity venous system.
The current therapy of shin ulcers involves both causal and local treatment. Causal treatment should include elimination or significant reduction of reflux in the lower extremity venous system, arterial revascularization, blood glucose level regulation and appropriate therapy for less common conditions. It is very important to perform concomitant local treatment that includes wound cleaning and stimulation of epithelialization. Local treatment methods
Robert Krzysztof Mlosek
Journal of Ultrasonography, Volume 20 , ISSUE 83, 254–260
N.I. De Leon,
International Journal on Smart Sensing and Intelligent Systems, Volume 7 , ISSUE 2, 519–536
Moreover, like other JAK inhibitors (Fedratinib or Ruxolitinib) Baricitinib may also reduce the effects of the increased cytokine levels that are frequently seen in patients with COVID-19. In vitro, Baricitinib reduces levels of cytokines implicated in COVID-19, including IL-2, IL-6, IL-10, IFN-γ, and G-CSF .
The safety of Baricitinib therapy, combined with Lopinavir/Ritonavir, in moderate COVID-19 pneumonia patients was positively evaluated in a pilot study (NCT04358614) . Baricitinib
Postępy Mikrobiologii - Advancements of Microbiology, Volume 59 , ISSUE 3, 207–225
Brenda J. Grossman
Immunohematology, Volume 16 , ISSUE 4, 160–161
For the surviving stroke patients that are affected physically and mentally, they are required rehabilitation after the stroke. Rehabilitation can be quite expensive on the patient and their families. The augmented reality rehabilitation gaming system aims to decrease the dependency on supervised therapy. This paper presents two augmented reality games. The games focus on rehabilitating stroke patients affected with upper limb disabilities. The games simulate current physical therapy techniques
N.I. De Leon,
International Journal on Smart Sensing and Intelligent Systems, Volume 7 , ISSUE 3, 1044–1058
Intravesical immunotherapy with attenuated strains of Mycobacterium bovis is a widely used therapeutic option in patients with non-muscle-invasive transitional cell carcinoma of the bladder. A rare complication of intravesical therapy with the Bacillus Calmette-Guérin vaccine is granulomatous prostatitis, which due to increasing levels of prostate-specific antigen and abnormalities found in transrectal examination of the prostate may suggest concomitant prostate cancer. A case of extensive
Journal of Ultrasonography, Volume 16 , ISSUE 67, 404–410
Nora Choque Olsson,
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 4 , ISSUE 2, 46–54
depression were both included in the screening, to get a clinical confirmation of the self-reported depressive symptoms. Adolescents meeting DSM-IV-TR criteria for any psychotic disorder, anorexia nervosa, bipolar disorder, intellectual disability or pervasive developmental disorders were excluded from the study. Eligible adolescents and parents provided written, informed consent and were then randomized to either Attachment Based Family Therapy (ABFT) or treatment as usual (TAU). The RCT study sample
Erling W. Rognli,
Nikolai O. Czajkowski,
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 41–51
Sickle cell disease (SCD) is an inherited blood disorder which can be complicated by stroke in infancy and childhood. The primary and secondary prevention of stroke in this patient population is regular RBC transfusion therapy at least every three weeks, but there is no consensus on the ideal RBC transfusion therapy. The Charles Drew Program, a partnership among a blood center and several hospitals affiliated with academic medical centers in Missouri, provides RBCs for the care of patients with
Edahn J. Isaak,
Michael R. DeBaun
Immunohematology, Volume 22 , ISSUE 3, 112–116
DAT is positive or negative, may detect anti-D for a few weeks after infusion of IV RhIG.
The encounter of true alloimmunization due to D+ RBCs resulting in anti-D is generally considered an unusual event in today’s pretransfusion testing setting, especially with current practices in place in transfusion therapy and obstetrical services to prevent the development of the antibody. Nevertheless, the detection of anti-D often prompts questions and actions by the transfusion
Immunohematology, Volume 35 , ISSUE 2, 51–60
Lawrence T. Goodnough,
James P. AuBuchon
Immunohematology, Volume 16 , ISSUE 3, 123–124
of hospitalization and general anaesthesia (Kimber & Schoeman, 2014).
Complications are also related to infection around the stoma, (van Laar, Nyholm, & Nyman, 2016) with reports of excessive granulation tissue, incision site erythema, abdominal pain, peritonitis and pneumoperitoneum (Fernandez et al., 2015; Zibetti et al., 2014). Zibetti et al (2014) noted infection tended to occur within one month of the PEG/J procedure and were successfully treated with antibiotic therapy, however device
Rachael Elizabeth Mackinnon
Australasian Journal of Neuroscience, Volume 27 , ISSUE 2, 1–4
The stated purpose of the meeting was to summarize „current, new and proven approaches in diagnostics and epilepsy therapy”, to define optimal clinical practice and scientific research areas, highlight advances in clinical and basic science and to identify future approaches or directions in epilepsy treatment.
Journal of Epileptology, Volume 22 , ISSUE 2, 123–125
Empiric therapy has been applied in the treatment of Lyme disease. This therapy is selected following the sensitivity analysis of the proposed drug in all species of bacteria which can cause a similar type of infection and on the basis of the clinical efficacy of antibiotic treatment. Established schemes based on data collected from many centers in the world, including type of antibiotic, dose and duration of his administration, and the stage and form of Lyme disease have been created. Number
Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 3, 335–339
Elles de Schipper,
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 3 , ISSUE 3, 147–168
Postępy Mikrobiologii - Advancements of Microbiology, Volume 59 , ISSUE 1, 63–74
present a case where PER was the last AED introduced in the treatment of a patient with EPC and individual seizures due to Rasmussen encephalitis before his seizure frequency could be reduced significantly. Results. A 44 years old male patient, who had been on a combination therapy of at least 4 AEDs since the age of 24, was admitted to our hospital presenting with an EPC. After the introduction of PER in the therapy EPC stopped and he remained seizure free for more than a year. Two of his other AEDs
Journal of Epileptology, Volume 24 , ISSUE 1, 67–70
motor block in the ulnar and median nerves which confirmed the diagnosis of MMN.
Mrs Smith had managed the disorder for nearly a decade with effective treatment options allowing her to maintain independence. The treatment Mrs Smith had been receiving for the past 6 years was intravenous immunoglobulin therapy (IVIg). MMN has no known cure, however therapies, such as immunoglobulin therapy, aim to reduce motor deficits, slow down ongoing axonal degeneration and promote remyelination (Léger, Guimarães
Madeline A Bone
Australasian Journal of Neuroscience, Volume 28 , ISSUE 2, 4–8
therapy has been noted to date. We report such a case recently encountered at our Fetal Center.
The patient was a 31-year-old woman (gravida/para/abortus [GPA] = G2P1000) who was referred to our Fetal Center from a neighboring state for evaluation of Vel alloimmunization. Her past history was significant, with the finding of a positive antibody detection test and identification of anti-Vel during her previous pregnancy. Based on literature reports of only mild-to-moderate HDFN in
Immunohematology, Volume 33 , ISSUE 4, 152–154
A patient with hemolytic disease of the newborn (HDN) due to maternal anti-Kpa alloimmunization is described. Although there are few reports in the literature, it appears that HDN due to anti-Kpa is often mild and transfusion therapy is rarely required. However, in this case, the baby’s hemoglobin progressively decreased and on day 18 a blood transfusion was administered, but jaundice was not severe enough for exchange transfusion.
Immunohematology, Volume 13 , ISSUE 2, 61–62
therapy(4–6). The cross-sectional area (CSA) of the median nerve within the carpal tunnel inlet and outlet is the parameter of interest measured to reflect the severity of CTS(7). As an extension to conventional US, sonoelastography (SE) has been introduced to map the local distribution of elasticity in biological tissues(8,9).
Elasticity is defined as the ability of an object to maintain its original size and shape after being stretched or compressed(10). Pathologically abnormal tissue exhibits
Yasemin Durum Polat,
Fikriye Sinem Ince,
Journal of Ultrasonography, Volume 20 , ISSUE 81, e90–e94
, 2006). Still only around 60% of patients are completely free from seizures or achieve substantial control, whereas 30% are refractory to this form of therapy. Patients who suffer from seizures in spite of the administration of two subsequent, appropriately-selected AEDs that are well applied and tolerated, are diagnosed with refractory epilepsy (Kwan et al., 2010). Seizures persisting despite treatment may cause developmental delay in children, cognitive impairment, poor life quality of the patient
Journal of Epileptology, Volume 26 , ISSUE 1-2, 27–47
, electronic selection of units antigen-matched at multiple blood group loci is then possible. This paper discusses the potential of this approach to improve transfusion therapy by reducing or eliminating alloantibody production in specific patient populations. These include patients facing long-term transfusion therapy and at high risk for sensitization; patients with warm autoantibodies when compatibility cannot be demonstrated by standard methods; and women for whom the production of
Connie M. Westhoff
Immunohematology, Volume 24 , ISSUE 4, 190–195
chemotherapeutic agents and antibiotics improves therapy efficiency, since it results in restoration of the equilibrium between the local and general pro- and anti-inflammatory response.
Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 2, 157–162
the auto anti-N, after corticosteroid therapy.
Caroline C. Immel,
Shauna N. Hay,
Linda R. Braddy,
Mark E. Brecher
Immunohematology, Volume 21 , ISSUE 2, 63–65
; therefore, corticosteroid therapy was started in the emergency department. It is well known that AIHA usually induces an increase in bone marrow RBC progenitors, and the consequence is an increase in MCV. One thing that alerted us was the high MCV, which in our case was extremely high. It has to be taken into account that increased RBC production also may result in folic acid deficiency and MA. In addition, positive DAT with IgG only and with complement C3 was found in 10 of 32 patients diagnosed with
R. De La Puerta,
Immunohematology, Volume 36 , ISSUE 3, 89–92
N. Rebecca Haley,
John P. Miller
Immunohematology, Volume 23 , ISSUE 2, 63–68
chart review, including serologic, hematology, and chemistry laboratory results, of two patients who developed red blood cell (RBC) autoantibodies during treatment with a checkpoint inhibitor. Serologic testing of blood samples from these patients during induction therapy with ipilimumab and nivolumab, respectively, showed their RBCs to be positive by the direct antiglobulin test (IgG+, C3+) and their plasma to contain panreactive RBC autoantibodies. Neither patient had evidence of hemolysis. Both
Laura L.W. Cooling,
Jonathon C. Mowers,
Sheri L. Hugan
Immunohematology, Volume 33 , ISSUE 1, 15–21
In children with sickle cell disease (SCD), primary and secondary prevention of strokes require indefinite regular blood transfusion therapy. The risks associated with repeated transfusions include alloimmunization and increased donor exposure. The Charles Drew Program is a directed blood donor program designed to lower donor exposure, decreasing the associated complications of transfusion; however, no evidence exists demonstrating the magnitude of the benefit to the recipient. Further, the use
Dionna O. Roberts,
Ricardo J. Wray,
Michael R. DeBaun
Immunohematology, Volume 28 , ISSUE 1, 7–12
. Applying the scanning pattern in outdoor mobility conditions. The scanning pattern is practiced in different traffic situations outside the therapy centre with increasing complexity. Patients walk, cycle or drive a mobility scooter, depending on their needs.
Studies investigating the effect of eye movement compensatory strategies, so far, have only compared the performance of participants in certain tasks, such as visual scanning or detecting obstacles while walking, before and after compensatory
Frans W. Cornelissen,
Gera de Haan
International Journal of Orientation & Mobility, Volume 11 , ISSUE 1, 7–19
Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 271–280
Polish Journal of Microbiology, Volume 66 , ISSUE 2, 265–268
Because of the functionality of an index finger, the disability of its motion in the modern age can decrease the person’s quality of life. As a part of rehabilitation therapy, the recognition of the index finger motion for rehabilitation purposes should be done properly. This paper proposes a novel recognition system of the index finger motion suing a cutting-edge method and its improvements. The proposed system consists of combination of feature extraction method, a dimensionality reduction
Adel Al Jumaily,
International Journal on Smart Sensing and Intelligent Systems, Volume 7 , ISSUE 2, 644–657
is most common in patients with AIDS. The pathogenesis and pathophysiology of the diseases is still incompletely understood, therefore no definitive effective therapy is currently available. Prevention is very difficult due to Acanthamoeba ubiquity and resistance. Further studies on effective solutions for the prevention and treatment of Acanthamoeba infections are needed.
Edyta B. Hendiger,
Jacek P. Szaflik
Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 4, 429–439
status, metabolic acidosis, abnormal liver function tests, and a severe coagulopathy. He was successfully resuscitated with uncrossmatched units of group O, D– blood, and after corticosteroid therapy he had complete resolution of his anti-Dmediated hemolysis.
Rachel S. Bercovitz,
Daniel R. Ambruso
Immunohematology, Volume 29 , ISSUE 1, 15–18
requisition of electrical therapy which stops arrhythmia , allowing the heart to re-establish the normal rhythm when compare to regular defibrillator it require minimal training to use. Biomedical monitoring promises to give an overview of cardiovascular system non -invasively and this will be easy to use and operate without hospitalization.
A . Priya
International Journal on Smart Sensing and Intelligent Systems, Volume 10 , ISSUE 5, 446–458
after immunosupression therapy. Nocardia asteroides is responsible for the majority of infections in humans. Diagnostic methods include cell culture and PCR. The symptoms vary depending on the form of the illness. Cough and hemoptysis are characteristic for pulmonary nocardiosis, while abscesses are typical for the cutaneous form. When the illness spreads, the symptoms vary depending on the organ. The treatment of choice is sulfonamide.
Mateusz Maciej Węclewicz,
Postępy Mikrobiologii - Advancements of Microbiology, Volume 57 , ISSUE 1, 68–75
made by Nobel laureate Professor Shinya Yamanaka (Takahashi and Yamanaka, 2006; Takahashi et al., 2007) more than a decade ago, the technology has advanced significantly. Professor Yamanaka’s research has undoubtedly contributed to all fields of science; however, primarily three applications are exceptionally relevant for iPSC-technology. These comprise novel drug development, regenerative therapy and disease modelling. Although the discovery of iPSC-technology has transformed biomedical research
Josefine Jul Jarbæk Nielsen,
Thea Pinholt Lillethorup,
Andreas Nørgaard Glud,
Jens Christian Hedemann Sørensen,
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 273–285
is a health problem as well as a social and economic one. Epilepsy affects over 65 million people worldwide (Ngugi et al., 2010).
Among people with epilepsy (PWE) and their healthcare providers, there are overlapping needs for improvement of patient education, self-management which directly influences, seizures management, diagnosis and therapy and medical data management. According to the several published studies, only 65–70% of PWE respond to current treatments to control their seizures
Journal of Epileptology, Volume 28 , 63–69
IgG sensitization.15 The DAT strength of reactivity can be as strong as 3+.19 An eluate would be nonreactive with group O screening cells but positive with A1 or B reverse typing cells by IAT depending on the patient’s ABO type. When a group A, B, or AB patient is found to have a positive DAT with an eluate that demonstrates isoagglutinin reactivity, determine whether the patient has received high-dose IVIg therapy within the last 3–5 days. The clinical team of such a patient should be alerted to
Immunohematology, Volume 35 , ISSUE 1, 13–15
Correction to: Rognli EW, Waraan L, Czajkowski NO, Aalberg A. Moderation of treatment effects by parent-adolescent conflict in a randomised controlled trial of Attachment Based Family Therapy for adolescent Depression. Scandinavian Journal of Child and Adolescent Psychiatry and Psychology 2020;8:110-122
The two figures in the original version of the paper Moderation of treatment effects by parent-adolescent conflict in a randomised controlled trial of Attachment Based Family Therapy for
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 9 , 27–29
ensure a scientific and safe therapy. Vision system sends the recognized acupoint position to the master system to track the patient’s body, and the acupoint being massaged is displayed in real time by the 3D virtual model. The robot can execute ten massage manipulations, so that the traditional Chinese massage can have a robot instead. The effectiveness for degenerative lumbago in middle-aged and aged is demonstrated by laboratory examination and clinical trial..
International Journal on Smart Sensing and Intelligent Systems, Volume 7 , ISSUE 3, 1024–1043
cardiovascular system (Najmanova et al., 2015), nervous system (Skalicka-Woźniak et al., 2016), body immunity (Rohini et al., 2014) and digestive system (Popp et al., 2017) are currently being researched. New derivatives are still being discovered and synthesized due to their potential uses.
Recent studies have revealed the effective use of coumarins in cancer therapy as medicaments and for mitigating the effects of radiotherapy (Rohini et al., 2014). One of the most common coumarins, warfarin (4
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 126–132
Legionella pneumophila, Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophila, Klebsiella pneumoniae, Serratia marcescens and Mycobacterium tuberculosis. There is a need for more research on free-living amoeba invasions in humans, particularly on the methods of diagnosis and appropriate forms of pharmacological therapy. Despite the undeniable role of free-living amoeba in the transmission of pathogenic bacteria, there is still insufficient amount of research and optimal diagnostic
Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 1, 106–112
clinical course, ITP in adults often lasts more than 6 months (chronic ITP) and is resistant to conventional treatment (corticosteroids, intravenous immune globulin, or splenectomy). The goal of medical management is to increase the platelet count to a safe level, without the risks of bacterial infections associated with splenectomy or toxicity from prolonged corticosteroid therapy. Splenectomy increases platelet counts in hours to days in most patients with acute ITP, but nearly 50 percent experience
S. Gerald Sandler
Immunohematology, Volume 20 , ISSUE 2, 112–117
Stroke affects about 975,000 people annually. Currently different robotic systems are used, such as exoskeletons that support motor rehabilitation, where they sometimes increase the patient’s possible recovery rate. But these systems are expensive and often require adequate locations for therapy routines. This article offers the mechanical design of an exoskeleton concept for human upper limbs that allows the attachment to the arm and forearm, offering protection, torque, and movement, plus the
International Journal on Smart Sensing and Intelligent Systems, Volume 10 , ISSUE 3, 491–505
specificity. The patient’s autoimmune anemia and thrombocytopenia responded well to discontinuing the immunosuppressant tacrolimus, transfusions with Kp(b–) RBCs, and intravenous immunoglobulin therapy, with disappearance of the pathologic antibody. During the autoimmune hemolysis, the patient’s RBCs did not react with antisera specific for Kpb. However, repeat testing of the patient’s RBCs with Kpb-specific antisera 15 months after the resolution of hemolysis showed reactivity
Scott A. Koepsell,
James D. Landmark
Immunohematology, Volume 30 , ISSUE 1, 14–17
transfusing the patient. We report a case of warm autoimmune hemolytic anemia (WAIHA) in which the transfusion of red cells was complicated by a febrile transfusion reaction. Evaluation of the reaction resulted in a significant delay in transfusion therapy. Subsequent administration of leukocyte-poor red cells resulted in uneventful transfusions with a good therapeutic response. Retrospective analysis of the pretransfusion sample demonstrated significant levels of anti-neutrophil antibodies. This case
Jeanne A. Lumadue,
Rosetta Sue Shirey,
Thomas S. Kickler,
Paul M. Ness
Immunohematology, Volume 12 , ISSUE 2, 84–86
common risk factor is the acquisition of resistance by bacteria living in human and animals as a result of the use of antibiotics, especially in unjustified situations, incorrect selection or dosing [27, 35, 45].
The aim of this study is to draw attention to the phenomenon of bacterial resistance in animals, which is as common as in human medicine, and to the resulting consequences in terms of therapy, animal welfare and threats to humans. Selected data on genes and their clusters encoding antibiotic
Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 259–270
The development of dynamic rehabilitation devices can be evaluated as a research fast-growing field. Indeed, robot-assisted therapy is an advanced new technology mainly in stroke rehabilitation. Although patients benefit from this enormous development of technology, including the presence of rehabilitation robots, the therapeutic field still suffering a lack in hand robotic rehabilitation devices. In this context, this work proposes a new design of a 3D printed hand exoskeleton for the stroke
Ismail Ben Abdallah,
International Journal on Smart Sensing and Intelligent Systems, Volume 10 , ISSUE 2, 341–366
the bacteria multiply. The treatment of brucellosis is based on two-drug therapy, the most common combinations of antibiotics are: doxycycline with rifampicin or fluoroquinolones with rifampicin. Currently, also other methods are used to disrupt Brucella intracellular replication (tauroursodeoxycholic acid or ginseng saponin fraction A).
Polish Journal of Microbiology, Volume 67 , ISSUE 2, 151–161
-year-old girl from Wisconsin in the USA – Jeanny Giese, who developed rabies a month after having her left index finger bitten by a bat, which took place on 12 September 2004 . Only 5 cases of people who did not die after being infected with the rabies virus had been known until this year. Each of these people underwent post-exposure prophylaxis in the form of administering a suitable vaccine. The girl from the USA, subjected to experimental therapy according to the Milwaukee protocol, was the
Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 2, 153–164
the development of vaccines all over the world. Vaccine development can take a minimum of 18 months.
Lack of antiviral treatment and antiviral treatment studies
In current times, there is no specific antiviral therapy to control this virus only supportive treatment for the coronavirus. Recombinant interferon only has a limited response with ribavirin against a coronavirus infection. The two viral protein inhibitors as an available option of treatment are Baricitinib (Janus and AAK1 kinases
Muhammad Aamir Aslam,
Muhammad Hassan Saeed,
Muhammad Haseeb Arif,
Postępy Mikrobiologii - Advancements of Microbiology, Volume 60 , ISSUE 1, 13–20
This paper reviews the recently developed techniques in biomagnetics and bioimaging such as transcranial magnetic stimulation (TMS), magnetic resonance imaging (MRI), and cancer therapy based on magnetic stimulation. A technique of localized and vectorial TMS has enabled us to obtain non-invasive functional mapping of the human brain. The development of new bioimaging technologies such as current distribution MRI and conductivity MRI potentially enables us to understand the dynamics of brain
International Journal on Smart Sensing and Intelligent Systems, Volume 1 , ISSUE 1, 300–314
diagnostic tests carried out in the shortest possible time also allows one to make appropriate decisions in the field of targeted therapy and prevention, in addition to contributing to the optimization of empirical therapy (microbiological map). Providing high-quality laboratory services guarantees good quality medicine.
Guidelines on quality standards for medical diagnostic and microbiological laboratories contained in Regulation of the Minister of Health from 23 March 2006 (Journal of Laws of 2016
Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 2, 205–211
used for providing pharmacological therapy: levodopa and dopamine agonist ropinirole. Levodopa Equivalent Dose Calculator (www.parkinsonsmeasurement.org) was used to determine the equivalent dosages of dopaminergic drugs. The target for DBS electrodes in the group of patients treated surgically was subthalamic nuclei (bilaterally). The mean time from implantation of DBS in the group of patients treated surgically was 30.28±44.16 months. Twenty-eight healthy volunteers who were age- and sex-matched
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 297–304
In order to investigate the structure of ideas, or schemata, of social networks, Martin (2017) investigated a very unusual set of three social networks. These are delusional social networks of alternative personalities described by a patient undergoing therapy for multiple personality disorder (David et al. 1996), now known as dissociative identity disorder (Kihlstrom 2005). In order to do this, Martin (2017) uses random graphs, specifically the dk-series model (Mahadevan et al
Journal of Social Structure, Volume 21 , ISSUE 1, 35–76
microbiome in IBD are a cause or a consequence of inflammation.
Pediatric-onset CD is on the increase worldwide (Benchimol et al. 2017; Ng et al. 2017). Many young patients present with an extensive and aggressive course of the disease, which is a real therapeutic challenge. Treatment of CD is a complex, multistage process and depends on the type and clinical activity of the illness. ECCO/ESPGHAN guidelines recommend the usage of exclusive enteral nutrition (EEN) as a first-line therapy to induce
Polish Journal of Microbiology, Volume 68 , ISSUE 1, 121–126
onset of action, which basically restricts their effectiveness, and hence the prerequisites of the therapy of depression are still unmet (Mojtabai, 2009; Richelson, 2013). Augmentation therapy as a second-line treatment is preferred over first-line monotherapy because the latter is associated with a lower success rate (60-70%) (Thase et al., 2007). The therapeutic potential of the new generation drugs like venlafaxine (a dual reuptake inhibitor), reboxetine (a selective NE-reuptake inhibitor) or
Sharon Ronald D'souza,
Pravin Popatrao Kale
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 217–224
population despite a comprehensive approach to RhIG therapy. Observations from this prospective patient management strategy include the need for improved application of guidelines for RhIG administration and improved quality of information provided to laboratories assessing RhIG eligibility. A laboratory process for prospective follow-up when unexpected anti-D is detected in pregnancy is recommended.
Judith L. Hannon,
Immunohematology, Volume 32 , ISSUE 3, 108–111
and accelerates the proliferation of this structure’s cells. Our study corroborates with the above study results proving the antidepressant effect in the RS group.
The paper also tested the antidepressant efficacy of combined therapy (VOR + DAP) to NS and RS rats. No antidepressant effect was found in the NS group either upon single or chronic administration, while in the RS group, immobility time was reduced upon chronic administration of the drugs. Moreover, it was found that prolonged combined
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 217–224
corticosterone levels (Van den Hove et al., 2005), is an effective method for achieving an animal model of depression.
Polypharmacotherapy, i.e., the combined use of drugs, is frequently utilized in the treatment of depression. Usually, the effects of an anti-depressant agent are discernable after 2–4 weeks of pharmacotherapy (Machado-Vieira et al., 2010), which is why they are increasingly used in combination therapy in an attempt to achieve the effect earlier. Apart from offering undoubted advantages
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 13–24
Parkinson’s disease (PD) is one of the most common age-related neurodegenerative disorders. Despite years of intense research and testing of candidate treatments, all available therapies are symptomatic. The long period of stealthy, relatively symptom-free development is shared with other neurodegenerative disorders (notably, with Alzheimer’s disease – AD), and hampers diagnosis, elucidation of disease mechanisms, and possible therapy (reviewed in Jęśko et al., 2017). The main
Anna M. Lenkiewicz,
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 277–290
supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses through axonal and dendritic sprouting (Kim et al., 2017). Chen et al. (2015) reported that neural plasticity was promoted by statin therapy through upregulation of Bdnf after stroke in mice. BDNF regulates neuronal survival, cell migration, and synaptic function. Thus, statins, along with increased Bdnf expression, can play an important role in improving and restoring brain tissue after
Iraj Jafari Anarkooli,
Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 413–420