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compatible with ICAO Standards and Recommended Practices (SARPs). In the following part, the process of risk assessment in air transport, based on the Safety Management Manual, using a safety risk tolerability matrix, is characterized. Finally, in this article, an exemplary risk analysis is carried out, focusing on a selected case arising from the ATM field. For the analysed case, safety risk hazards and their possible effects are identified and then assigned to the Intolerable, Tolerable and Acceptable


Transport Problems, Volume 15 , ISSUE 2, 143–156


The short-term efficacy of combined hormone therapy in West syndrome

different countries. In the USA the natural ACTH is used, whereas in Europe – its synthetic version, tetracosactide (Riikonen, 2014) is used. In some countries, ACTH or tetracosactide is not approved; therefore corticosteroids (prednisolone, hydrocortisone, and dexamethasone) are mainly used. The data on the efficacy and tolerability of corticosteroids versus ACTH are different (Arya et al., 2012; Go et al., 2012; Jones et al., 2015). Comparative trials on efficacy and tolerability of various hormone

Iosif V. Volkov, Oksana K. Volkova, Olga S. Tashkinova, Elena D. Belousova

Journal of Epileptology, Volume 26 , ISSUE 1-2, 55–61


Rational polytherapy: Myth or reality?

., equal drug loads) may also bring some insight into whether the increased effectiveness of a combination of AEDs (either with the same or different MoAs) is due to an improvement in efficacy or in tolerability. A robust study looking at the monotherapy versus polytherapy focussing primarily on tolerability did not show evidence of differences in overall efficacy and neurotoxicity between the two regimes in which AEDs were started in equal dose loads (Deckers et al., 2001). Clinical efficacy has been

José Pimentel, José Manuel Lopes Lima

Journal of Epileptology, Volume 27 , 27–34

Original Paper

Russian experience of using perampanel in daily clinical practice. Preliminary report

Pavel Vlasov, Vladimir Karlov, Irina Zhidkova, Aleksandr Chervyakov, Oleg Belyaev, Iosif Volkov, Diana Dmitrenko, Antonina Karas, Tatiana Kazennykh, Olga Miguskina, Anna Moskvicheva, Elena Paramonova, Irina Ponomareva

Journal of Epileptology, Volume 24 , ISSUE 1, 7–14

Review Paper

Anticonvulsant therapy in brain-tumor related epilepsy

seizures does not differ substantially from that applied to epilepsies from other etiologies. Therefore, the choice of an AED is based, above all, on tolerability and pharmacokinetic interactions with chemotherapeutic drugs. Levetiracetam is recommended by many authors as first-line therapy in brain tumor-related epilepsy. Due to the possibility of interactions, the combination of enzyme-inducing AEDs and chemotherapeutic drugs, is usually not recommended as a first choice. Currently there is no

Walter Fröscher, Timo Kirschstein, Johannes Rösche

Journal of Epileptology, Volume 24 , ISSUE 1, 41–56

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