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Review | 15-January-2019

c-Fos and neuronal plasticity: the aftermath of Kaczmarek’s theory

The development of molecular biology methods in the early 1980s led to a better understanding of the role of transcription factors in mammalian cells. The discovery that some transcription factors are critically important for cells to switch between different functional states was fundamental for modern molecular neurobiology. In the 1980s Leszek Kaczmarek proposed that, analogically to the cell cycle or to cell differentiation, long-term synaptic plasticity, learning, and memory should also

Jacek Jaworski, Katarzyna Kalita, Ewelina Knapska

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 287–296

Article | 22-January-2021

The P1PK blood group system: revisited and resolved

be made.2 Fig. 1 Transcriptional regulation determines the two major phenotypes in the P1PK blood group system, P1 and P2. A schematic illustration (not to scale) of the A4GALT gene coding for the P1Pk synthase is shown. The single nucleotide variant rs5751348:G>T disrupts a transcription factor binding motif, since EGR1 and RUNX1 (and possibly KLF1) bind to the P1 allele over the rs5751348:G and surrounding site, but have lowered affinity to the P2 allele carrying the variant. The transcription

L. Stenfelt, Å. Hellberg, J.S. Westman, M.L. Olsson

Immunohematology, Volume 36 , ISSUE 3, 99–103

research-paper | 30-November-2020

Inhibition of ionotropic GluR signaling preserves oligodendrocyte lineage and myelination in an ex vivo rat model of white matter ischemic injury

that express a set of markers such as PDGFαR and proteoglycan NG2, to mature OLs that express myelin genes such as myelin–associated glycoprotein (MAG), myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP), 2’–3’–cyclic nucleotide 3’ phosphohydrolase (CNP), and proteolipid protein (PLP) (McTigue et al., 2001; Rivers et al., 2008). Regulation of the OL development is multifactorial, and many transcriptional factors including bHLH transcription factors (e.g., Olig1, and Olig2) and a

Mohamed A. Al-Griw, Michael G. Salter, Ian C. Wood

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 233–248

research-article | 30-November-2019

Detoxification-related gene expression accompanies anhydrobiosis in the foliar nematode (Aphelenchoides fragariae)

large class of transcription factors (over 280 in C. elegans). In most cases, NHRs bind lipophilic hormones, e.g. steroids, retinoids, and fatty acids, and also regulate gene expression through the integration of endogenous and exogenous signals. Specific NHRs, such as NHR-8 and NHR-48 in C. elegans and DHR96 in Drosophila, regulate xenobiotic detoxification network in response to environmental conditions (Hoffmann and Partridge, 2015). A gene (DN12692_c0_g8) in our data set that is homologous to

Zhen Fu, Paula Agudelo, Christina E. Wells

Journal of Nematology, Volume 52 , 1–12

Article | 30-July-2021

Expression of neural crest markers by human embryonic stem cells: an introductory project

well be of use to all clinicians interested in the management of these tissues. Aim: The present study was designed to determine if the early addition of noggin (a bone morphogenetic protein (BMP) antagonist) and/or the late addition of BMP4 would increase the expression of the transcription factors: Msx-1, Snail, Slug and Pax-7. Method: This involved an assessment of the effects of early addition ( Days 0 to 3) of noggin and/or the late addition ( Days 4 to 7) of BMP4 on the expression of the

Anita Bonic, Mack Poon, Michael G. Woods, Alan O. Trounson

Australasian Orthodontic Journal, Volume 32 , ISSUE 2, 175–183

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