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  • Acta Neurobiologiae Experimentalis

 

Research paper | 01-August-2017

Rat white matter injury model induced by endothelin-1 injection: technical modification and pathological evaluation

White matter injury is an important cause of functional disability of the brain. We comprehensively analyzed a modified endothelin-1 (ET-1) injection-induced white matter injury model in the rat which is very valuable for investigating the underlying mechanisms of subcortical ischemic stroke. ET-1 was stereotactically injected into the internal capsule of the rat. To avoid complications with leakage of ET-1 into the lateral ventricle, the safest trajectory angle to the target was established

Hideaki Ono, Hideaki Imai, Satoru Miyawaki, Hirofumi Nakatomi, Nobuhito Saito

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 212–224

research-paper | 30-November-2020

Inhibition of ionotropic GluR signaling preserves oligodendrocyte lineage and myelination in an ex vivo rat model of white matter ischemic injury

INTRODUCTION Increasing evidence suggest that there are many factors potentially involved in the impaired brain development in preterm infants (Ogawa et al., 2020). Among these is the excitotoxic injury (Salter and Fern, 2005; Fern and Matute, 2019; Ogawa et al., 2020). All these disturbances could lead to impaired oligodendrocyte (OL) maturation, cell death, a loss of appropriate myelination, and eventually – development of the condition named “white matter injury (WMI)” and neurological

Mohamed A. Al-Griw, Michael G. Salter, Ian C. Wood

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 233–248

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