SEARCHING FOR CAUSES OF NECROTISING ENTEROCOLITIS. AN APPLICATION OF PROPENSITY MATCHING

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Statistics in Transition New Series

Polish Statistical Association

Central Statistical Office of Poland

Subject: Economics , Statistics & Probability

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ISSN: 1234-7655
eISSN: 2450-0291

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VOLUME 19 , ISSUE 1 (March 2018) > List of articles

SEARCHING FOR CAUSES OF NECROTISING ENTEROCOLITIS. AN APPLICATION OF PROPENSITY MATCHING

Nicholas T. Longford

Keywords : causal analysis, National Neonatal Research Database, necrotising enterocolitis, potential outcomes framework, preterm birth, propensity matching

Citation Information : Statistics in Transition New Series. Volume 19, Issue 1, Pages 87-117, DOI: https://doi.org/10.21307/stattrans-2018-006

License : (CC BY-NC-ND 4.0)

Published Online: 27-May-2018

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ABSTRACT

Necrotising enterocolitis (NEC) is a disease of the gastrointestinal tract afflicting preterm-born infants in the first few weeks of their lives. We estimate the effect of changing the feeding regimen of infants in their first 14 postnatal days by analysing the data from the UK National Neonatal Research Database. We avoid some problems with drawing causal inferences from observational data by reducing the analysis to the infants who spent the first 14 postnatal days (or longer) in neonatal care and for whom NEC was not suspected in this period. This reduction enables us to use summaries of the feeding regimen in this period as background variables in a potential outcomes framework. Large size of the cohort is a distinct advantage of our study. Its results inform the design of a randomised clinical trial for preventing NEC, and the choice of its active treatment(s) in particular.

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